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| Description | NUAK family SNF1-like kinase 2 |
|---|
Gene and Protein Information
| Gene ID | 81788 |
|---|---|
| Uniprot Accession IDs | Q9H093 |
| Ensembl ID | ENSP00000356125 |
| Symbol | OMPHK2 SNARK SNARK |
| Family | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. |
| Sequence | MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAEGVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPSGAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPLGDSCFSLTDCQEVTATYRQALRVCSKLT Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 457667 | NUAK2 | NUAK family kinase 2 | 9598 | VGNC:11561 | OMA, EggNOG |
| Macaque | 700529 | NUAK2 | NUAK family kinase 2 | 9544 | Inparanoid, OMA, EggNOG | |
| Mouse | 74137 | Nuak2 | NUAK family, SNF1-like kinase, 2 | 10090 | MGI:1921387 | Inparanoid, OMA, EggNOG |
| Rat | 289419 | Nuak2 | NUAK family kinase 2 | 10116 | RGD:1359167 | Inparanoid, OMA, EggNOG |
| Dog | 488570 | NUAK2 | NUAK family kinase 2 | 9615 | VGNC:53124 | Inparanoid, OMA, EggNOG |
| Horse | 100054893 | NUAK2 | NUAK family kinase 2 | 9796 | VGNC:49425 | Inparanoid, OMA, EggNOG |
| Anole lizard | 100556388 | nuak2 | NUAK family kinase 2 | 28377 | Inparanoid, OMA, EggNOG | |
| Xenopus | 100158605 | nuak2 | NUAK family, SNF1-like kinase, 2 | 8364 | XB-GENE-5857794 | OMA, EggNOG |
| Zebrafish | 560275 | nuak2 | NUAK family, SNF1-like kinase, 2 | 7955 | ZDB-GENE-050208-563 | Inparanoid, EggNOG |
Protein Classes
PANTHER Classes
protein / non-receptor serine/threonine protein kinase / Nuak family snf1-like kinase 2
protein / protein kinase / Nuak family snf1-like kinase 2
protein / transferase / Nuak family snf1-like kinase 2
protein / kinase / Nuak family snf1-like kinase 2
protein / non-receptor serine/threonine protein kinase / Nuak family snf1-like kinase 2
protein / protein kinase / Nuak family snf1-like kinase 2
protein / transferase / Nuak family snf1-like kinase 2
protein / kinase / Nuak family snf1-like kinase 2
DTO Classes
protein / Kinase / Protein kinase / CAMK group / CAMKL family / NuaK subfamily / Nuak family snf1-like kinase 2
protein / Kinase / Protein kinase / CAMK group / CAMKL family / NuaK subfamily / Nuak family snf1-like kinase 2
Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Direct Associated Targets | Disease Type | Mondoid |
|---|---|---|---|
| adult high grade glioma | 4998 | Expression Atlas | MONDO:0100342 |
| Astrocytoma, Pilocytic | 3186 | Expression Atlas | MONDO:0016691 |
| atypical teratoid / rhabdoid tumor | 5491 | Expression Atlas | MONDO:0020560 |
| breast cancer | 3880 | Expression Atlas | MONDO:0007254 |
| cystic fibrosis | 1831 | Expression Atlas | MONDO:0009061 |
| ependymoma | 5607 | Expression Atlas | MONDO:0021191 |
| esophageal adenocarcinoma | 754 | Expression Atlas | MONDO:0005028 |
| glioblastoma | 5998 | Expression Atlas | MONDO:0018177 |
| interstitial cystitis | 2307 | Expression Atlas | MONDO:0018301 |
| intraductal papillary-mucinous adenoma (IPMA) | 2987 | Expression Atlas | MONDO:0004381 |
Bibliography
| 1.Hartley, J L JL, Temple, G F GF and Brasch, M A MA. 2000-11 DNA cloning using in vitro site-specific recombination. [PMID:11076863] |
| 2.Wiemann, S S and 23 more authors. 2001-03 Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. [PMID:11230166] |
| 3.Simpson, J C JC, Wellenreuther, R R, Poustka, A A, Pepperkok, R R and Wiemann, S S. 2000-09 Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. [PMID:11256614] |
| 4.Lefebvre, D L DL and 6 more authors. 2001-04-15 Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. [PMID:11284715] |
| 5.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932] |
| 6.Suzuki, Atsushi A and 5 more authors. 2003-11-07 Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. [PMID:14575707] |
| 7.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039] |
| 8.Lizcano, Jose M JM and 10 more authors. 2004-02-25 LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. [PMID:14976552] |
| 9.Legembre, Patrick P, Schickel, Robert R, Barnhart, Bryan C BC and Peter, Marcus E ME. 2004-11-05 Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness. [PMID:15345718] |
| 10.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334] |