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CD38

DescriptionADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene and Protein Information

Gene ID952
Uniprot Accession IDs P28907 O00121 O00122 Q96HY4
Ensembl ID ENSP00000226279
Symbol ADPRC1 ADPRC 1
FamilyBelongs to the ADP-ribosyl cyclase family.
Sequence
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp745433CD38CD38 molecule9598VGNC:6415OMA, EggNOG
Macaque714399CD38CD38 molecule9544Inparanoid, OMA, EggNOG
Mouse12494Cd38CD38 antigen10090MGI:107474Inparanoid, OMA, EggNOG
Rat25668Cd38CD38 molecule10116RGD:2303Inparanoid, OMA, EggNOG
Dog403756CD38CD38 molecule9615VGNC:38953Inparanoid, OMA, EggNOG
Horse100068959CD38CD38 molecule9796VGNC:51151Inparanoid, OMA, EggNOG
Cow327677CD38CD38 molecule9913VGNC:27027Inparanoid, OMA, EggNOG
Pig100511702CD38CD38 molecule9823Inparanoid, OMA, EggNOG
Opossum103094598CD38CD38 molecule13616Inparanoid, OMA, EggNOG
Platypus100074315CD38CD38 molecule9258OMA, EggNOG
Chicken422827CD38CD38 molecule9031CGNC:10783Inparanoid, OMA, EggNOG
Xenopus496666cd38CD38 molecule8364XB-GENE-945949Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    hydrolase    /    cyclase    /    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
protein    /    hydrolase    /    glycosidase    /    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
DTO Classes
protein    /    Enzyme    /    Lyase    /    Cyclase    /    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      astrocytic glioma3773Expression AtlasMONDO:0021636
      chronic lymphocytic leukemia479Expression AtlasMONDO:0004948
      cutaneous lupus erythematosus1094Expression AtlasMONDO:0005282
      Duchenne muscular dystrophy609Expression AtlasMONDO:0010679
      interstitial cystitis2307Expression AtlasMONDO:0018301
      lung cancer4468Expression AtlasMONDO:0008903
      lung carcinoma2913Expression AtlasMONDO:0005138
      osteosarcoma7970Expression AtlasMONDO:0009807
      periodontitis245Expression AtlasMONDO:0005076
      primary Sjogren syndrome1657Expression AtlasMONDO:0010030

      Bibliography

      1. and Guse, A H AH. 1999-05 Cyclic ADP-ribose: a novel Ca2+-mobilising second messenger. [PMID:10376802]
      2.Funaro, A A and Malavasi, F F.Human CD38, a surface receptor, an enzyme, an adhesion molecule and not a simple marker. [PMID:10432444]
      3.Sun, L L and 16 more authors. 1999-09-06 CD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorption. [PMID:10477767]
      4.Adebanjo, O A OA and 12 more authors. 1999-11 A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis. [PMID:10559984]
      5.Cho, Y S YS and 5 more authors. 2000-01-21 Direct interaction of the CD38 cytoplasmic tail and the Lck SH2 domain. Cd38 transduces T cell activation signals through associated Lck. [PMID:10636863]
      6.Han, M K MK, Cho, Y S YS, Kim, Y S YS, Yim, C Y CY and Kim, U H UH. 2000-07-07 Interaction of two classes of ADP-ribose transfer reactions in immune signaling. [PMID:10777496]
      7.Pfister, M M and 5 more authors. 2001-11 NAD degradation and regulation of CD38 expression by human monocytes/macrophages. [PMID:11683883]
      8.Deaglio, Silvia S and 7 more authors. 2002-04-01 Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells. [PMID:11895784]
      9.Liu, Hsingjin H and Verfaillie, Catherine M CM. 2002-06 Myeloid-lymphoid initiating cells (ML-IC) are highly enriched in the rhodamine-c-kit(+)CD33(-)CD38(-) fraction of umbilical cord CD34(+) cells. [PMID:12063025]
      10.Antonelli, A A and 7 more authors. 2002-09 Autoimmunity to CD38 and GAD in Type I and Type II diabetes: CD38 and HLA genotypes and clinical phenotypes. [PMID:12242463]