Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

PLA2G7

DescriptionPlatelet-activating factor acetylhydrolase

Gene and Protein Information

Gene ID7941
Uniprot Accession IDs A5HTT5 Q15692 Q5VTT1 Q8IVA2 PAF acetylhydrolase
Ensembl ID ENSP00000274793
Symbol PAFAH PAFAD PAFAH LP-PLA2 LDL-PLA2
FamilyBelongs to the AB hydrolase superfamily. Lipase family.
Sequence
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
Show more
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp462744PLA2G7phospholipase A2 group VII9598VGNC:10021OMA, EggNOG
Macaque704566PLA2G7phospholipase A2 group VII9544Inparanoid, OMA, EggNOG
Mouse27226Pla2g7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)10090MGI:1351327Inparanoid, OMA, EggNOG
Rat301265Pla2g7phospholipase A2 group VII10116RGD:1310734Inparanoid, OMA, EggNOG
Dog403848PLA2G7phospholipase A2 group VII9615VGNC:44632Inparanoid, OMA, EggNOG
Horse100055841PLA2G7phospholipase A2 group VII9796VGNC:21519Inparanoid, OMA, EggNOG
Cow282311PLA2G7phospholipase A2 group VII9913VGNC:32965Inparanoid, OMA, EggNOG
Pig396593PLA2G7phospholipase A2 group VII9823OMA, EggNOG
Opossum100014547PLA2G7phospholipase A2 group VII13616Inparanoid, OMA, EggNOG
Chicken395816PLA2G7phospholipase A2 group VII9031CGNC:12528Inparanoid, OMA, EggNOG
Anole lizard100563319pla2g7phospholipase A2 group VII28377Inparanoid, OMA
Xenopus100379949pafah2platelet-activating factor acetylhydrolase 28364XB-GENE-5997844Inparanoid, OMA, EggNOG
Zebrafish406470pla2g7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)7955ZDB-GENE-040426-2248Inparanoid, OMA, EggNOG
C. elegans172120paf-11-alkyl-2-acetylglycerophosphocholine esterase6239Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    hydrolase    /    esterase    /    Platelet-activating factor acetylhydrolase
DTO Classes
protein    /    Enzyme    /    Hydrolase    /    Esterase    /    Platelet-activating factor acetylhydrolase

Associated Recombinant Proteins

The page will load shortly, Thanks for your patience!
NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

The page will load shortly, Thanks for your patience!
NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      Platelet-activating factor acetylhydrolase deficiency1UniProt DiseaseMONDO:0013663
      Asthma168UniProt DiseaseMONDO:0004979
      Atopic hypersensitivity0UniProt Disease
      Ige Responsiveness, Atopic8MonarchMONDO:0007817
      Hypersensitivity, Immediate0Monarch
      Platelet-Activating Factor Acetylhydrolase Deficiency1MonarchMONDO:0013663
      Asthma, susceptibility to11MonarchMONDO:0010940
      Astrocytoma, Pilocytic3186Expression AtlasMONDO:0016691
      atopic dermatitis916Expression AtlasMONDO:0004980
      COPD393Expression AtlasMONDO:0005002

      Bibliography

      1.Lecointe, N N, Meerabux, J J, Ebihara, M M, Hill, A A and Young, B D BD. 1999-05-06 Molecular analysis of an unstable genomic region at chromosome band 11q23 reveals a disruption of the gene encoding the alpha2 subunit of platelet-activating factor acetylhydrolase (Pafah1a2) in human lymphoma. [PMID:10362256]
      2.Kruse, S S and 11 more authors. 2000-05 The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. [PMID:10733466]
      3.Howard, K M KM and Olson, M S MS. 2000-06-30 The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats. [PMID:10748027]
      4.Balta, G G, Gurgey, A A, Kudayarov, D K DK, Tunc, B B and Altay, C C. 2001-02-15 Evidence for the existence of the PAF acetylhydrolase mutation (Val279Phe) in non-Japanese populations: a preliminary study in Turkey, Azerbaijan, and Kyrgyzstan. [PMID:11248283]
      5.Min, J H JH and 6 more authors. 2001-04-17 Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme. [PMID:11294621]
      6.Quarck, R R and 12 more authors. 2001-05-22 Adenovirus-mediated gene transfer of human platelet-activating factor-acetylhydrolase prevents injury-induced neointima formation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice. [PMID:11369691]
      7.Feng, Y Y and Walsh, C A CA. 2001-06 Protein-protein interactions, cytoskeletal regulation and neuronal migration. [PMID:11389474]
      8.Yamada, Y Y, Ichihara, S S, Izawa, H H, Tanaka, M M and Yokota, M M. 2001 Association of a G994 --> T (Val279 --> Phe) polymorphism of the plasma platelet-activating factor acetylhydrolase gene with myocardial damage in Japanese patients with nonfamilial hypertrophic cardiomyopathy. [PMID:11501940]
      9.Unno, Naoki N and 8 more authors. 2002-02 Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese. [PMID:11807372]
      10.Ito, Teruhiko T and 9 more authors. 2002-01 Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm. [PMID:11810302]