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GRIN3A

DescriptionGlutamate receptor ionotropic, NMDA 3A

Gene and Protein Information

Gene ID116443
Uniprot Accession IDs B3DLF9 Q5VTR3 Q8TF29 Q8WXI6 GluN3A
Ensembl ID ENSP00000355155
Symbol KIAA1973 NR3A GluN3A NMDAR-L
FamilyBelongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily.
Sequence
MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAEALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp736408GRIN3Aglutamate ionotropic receptor NMDA type subunit 3A9598VGNC:8892OMA, EggNOG
Macaque716892GRIN3Aglutamate ionotropic receptor NMDA type subunit 3A9544Inparanoid, OMA, EggNOG
Mouse242443Grin3aglutamate receptor ionotropic, NMDA3A10090MGI:1933206Inparanoid, OMA, EggNOG
Rat191573Grin3aglutamate ionotropic receptor NMDA type subunit 3A10116RGD:621704Inparanoid, OMA
Dog474789GRIN3Aglutamate ionotropic receptor NMDA type subunit 3A9615VGNC:41496Inparanoid, OMA, EggNOG
HorseGRIN3Aglutamate ionotropic receptor NMDA type subunit 3A [Source:HGNC Symbol;Acc:HGNC:16767]9796OMA, EggNOG
Cow100295209GRIN3Aglutamate ionotropic receptor NMDA type subunit 3A9913VGNC:29650Inparanoid, OMA, EggNOG
Opossum100022944GRIN3Aglutamate ionotropic receptor NMDA type subunit 3A13616Inparanoid, OMA
Platypus100080844GRIN3Aglutamate ionotropic receptor NMDA type subunit 3A9258Inparanoid, OMA, EggNOG
Chicken769001GRIN3Aglutamate ionotropic receptor NMDA type subunit 3A9031CGNC:11596Inparanoid, OMA, EggNOG
Anole lizard100565030grin3aglutamate ionotropic receptor NMDA type subunit 3A28377Inparanoid, OMA, EggNOG
XenopusGRIN3Aglutamate ionotropic receptor NMDA type subunit 3A [Source:HGNC Symbol;Acc:HGNC:16767]8364OMA, EggNOG

Protein Classes

DTO Classes
protein    /    Ion channel    /    Glutamate-gated ion channel (GIC) Family of Neurotransmitter Receptors    /    NR3A/GRIN3A subfamily    /    Glutamate receptor ionotropic, NMDA 3A

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Wang, P P, Barks, J D JD and Silverstein, F S FS. 1999-01 Tat, a human immunodeficiency virus-1-derived protein, augments excitotoxic hippocampal injury in neonatal rats. [PMID:10197777]
      2.Perez-Otano, I I and 6 more authors. 2001-02-15 Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. [PMID:11160393]
      3.Haughey, N J NJ, Nath, A A, Mattson, M P MP, Slevin, J T JT and Geiger, J D JD. 2001-08 HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. [PMID:11483648]
      4.Chan, S F SF and Sucher, N J NJ. 2001-10-15 An NMDA receptor signaling complex with protein phosphatase 2A. [PMID:11588171]
      5.Bonavia, R R and 5 more authors. 2001-10-26 HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons. [PMID:11606043]
      6.Andersson, O O, Stenqvist, A A, Attersand, A A and von Euler, G G. 2001-12 Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B. [PMID:11735224]
      7.Nagase, T T, Kikuno, R R and Ohara, O O. 2001-12-31 Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. [PMID:11853319]
      8.Eriksson, Maria M and 8 more authors. 2002-03-22 Cloning and expression of the human N-methyl-D-aspartate receptor subunit NR3A. [PMID:11880201]
      9.Al-Hallaq, Rana A RA and 5 more authors. 2002-11 Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits. [PMID:12391275]
      10.Prendergast, Mark A MA and 6 more authors. 2002-11-08 Neurotoxic effects of the human immunodeficiency virus type-1 transcription factor Tat require function of a polyamine sensitive-site on the N-methyl-D-aspartate receptor. [PMID:12414113]