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PPARD

DescriptionPeroxisome proliferator-activated receptor delta

Gene and Protein Information

Gene ID5467
Uniprot Accession IDs A8K6J6 B4E3V3 B6ZGS1 B7Z3W1 E9PE18 Q5D1P0 Q7Z5K0 Q9BUD4 PPAR-delta
Ensembl ID ENSP00000310928
Symbol NR1C2 PPARB FAAR NUC1 NUCI NR1C2 NUCII PPARB
FamilyBelongs to the nuclear hormone receptor family. NR1 subfamily.
Sequence
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp463188PPARDperoxisome proliferator activated receptor delta9598VGNC:7904OMA, EggNOG
Macaque718861PPARDperoxisome proliferator activated receptor delta9544Inparanoid, OMA, EggNOG
Mouse19015Ppardperoxisome proliferator activator receptor delta10090MGI:101884Inparanoid, OMA, EggNOG
Rat25682Ppardperoxisome proliferator-activated receptor delta10116RGD:3370Inparanoid, OMA, EggNOG
Dog481756PPARDperoxisome proliferator activated receptor delta9615VGNC:44835Inparanoid, OMA
Horse100053404PPARDperoxisome proliferator activated receptor delta9796VGNC:21715Inparanoid, OMA
Cow353106PPARDperoxisome proliferator activated receptor delta9913VGNC:33182Inparanoid, OMA
Pig397297PPARDperoxisome proliferator activated receptor delta9823Inparanoid, OMA
Opossum100026039PPARDperoxisome proliferator activated receptor delta13616Inparanoid, OMA
Chicken395479PPARDperoxisome proliferator activated receptor delta9031CGNC:1862Inparanoid, OMA
Anole lizard100552327ppardperoxisome proliferator activated receptor delta28377Inparanoid, OMA
Xenopus100038152ppardperoxisome proliferator activated receptor delta8364XB-GENE-481495Inparanoid, OMA
Zebrafish30750ppardaperoxisome proliferator-activated receptor delta a7955ZDB-GENE-990415-212Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    transcription factor    /    Peroxisome proliferator-activated receptor delta
protein    /    receptor    /    Peroxisome proliferator-activated receptor delta
protein    /    nucleic acid binding    /    Peroxisome proliferator-activated receptor delta
protein    /    C4 zinc finger nuclear receptor    /    Peroxisome proliferator-activated receptor delta
DTO Classes
protein    /    Nuclear receptor    /    Peroxisome proliferator-activated receptors    /    Peroxisome proliferator-activated receptor delta

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      astrocytoma3773Expression AtlasMONDO:0021636
      intraductal papillary-mucinous carcinoma (IPMC)3017Expression AtlasMONDO:0004285
      medulloblastoma, large-cell6269Expression AtlasMONDO:0002791
      ovarian cancer8576Expression AtlasMONDO:0008170
      psoriasis6696Expression AtlasMONDO:0005083
      Cardiomegaly0CTD
      Cardiomyopathies161CTDMONDO:0004994
      Fatty Liver72CTDMONDO:0004790
      Liver Diseases, Alcoholic4CTDMONDO:0043693
      Melanoma246CTDMONDO:0005105

      Bibliography

      1.Xu, H E HE and 11 more authors. 1999-03 Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. [PMID:10198642]
      2.He, T C TC, Chan, T A TA, Vogelstein, B B and Kinzler, K W KW. 1999-10-29 PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. [PMID:10555149]
      3.Kraus, W L WL, Manning, E T ET and Kadonaga, J T JT. 1999-12 Biochemical analysis of distinct activation functions in p300 that enhance transcription initiation with chromatin templates. [PMID:10567538]
      4.Kersten, S S, Desvergne, B B and Wahli, W W. 2000-05-25 Roles of PPARs in health and disease. [PMID:10839530]
      5.Skogsberg, J J and 6 more authors. 2000-07 Characterization of the human peroxisome proliferator activated receptor delta gene and its expression. [PMID:10851270]
      6.Peters, J M JM and 8 more authors. 2000-07 Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). [PMID:10866668]
      7.Yi, Y W YW and 5 more authors. 2000-05-27 Gadd45 family proteins are coactivators of nuclear hormone receptors. [PMID:10872826]
      8.Bastie, C C, Luquet, S S, Holst, D D, Jehl-Pietri, C C and Grimaldi, P A PA. 2000-12-08 Alterations of peroxisome proliferator-activated receptor delta activity affect fatty acid-controlled adipose differentiation. [PMID:10991946]
      9.Park, B H BH, Vogelstein, B B and Kinzler, K W KW. 2001-02-27 Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells. [PMID:11226285]
      10.Hatae, T T, Wada, M M, Yokoyama, C C, Shimonishi, M M and Tanabe, T T. 2001-12-07 Prostacyclin-dependent apoptosis mediated by PPAR delta. [PMID:11551955]