LIG1

DescriptionDNA ligase 1

Gene and Protein Information

Gene ID3978
Uniprot Accession IDs B2RAI8 B4DTU4 Q2TB12 Q32P23
Ensembl ID ENSP00000263274
FamilyBelongs to the ATP-dependent DNA ligase family.
Sequence
MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGEDSGSDPEDTY
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp468936LIG1DNA ligase 19598VGNC:10202OMA, EggNOG
Macaque718528LIG1DNA ligase 19544Inparanoid, OMA, EggNOG
Mouse16881Lig1ligase I, DNA, ATP-dependent10090MGI:101789Inparanoid, OMA, EggNOG
Rat100911727LOC100911727DNA ligase 1-like10116RGD:6491367Inparanoid, OMA, EggNOG
Dog100686967LIG1DNA ligase 19615VGNC:42673Inparanoid, OMA, EggNOG
Horse100053186LIG1DNA ligase 19796VGNC:19663Inparanoid, OMA, EggNOG
Cow100124507LIG1DNA ligase 19913VGNC:30882Inparanoid, OMA, EggNOG
Pig100520434LIG1DNA ligase 19823Inparanoid, OMA, EggNOG
Platypus100086878LIG1DNA ligase 19258OMA, EggNOG
Anole lizard100565521lig1DNA ligase 128377Inparanoid, OMA, EggNOG
Xenopus100271763lig1ligase I, DNA, ATP-dependent8364XB-GENE-1009779Inparanoid, OMA, EggNOG
Zebrafish556995lig1ligase I, DNA, ATP-dependent7955ZDB-GENE-110404-2OMA, EggNOG
C. elegans179502lig-1DNA ligase 16239Inparanoid, OMA, EggNOG
Fruitfly37791DNA-ligIDNA ligase I7227FBgn0262619Inparanoid, OMA, EggNOG
S.cerevisiae851391CDC9DNA ligase (ATP) CDC94932S000002323Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    nucleic acid binding    /    DNA binding protein    /    DNA ligase 1
protein    /    nucleic acid binding    /    DNA ligase    /    DNA ligase 1
protein    /    nucleic acid binding    /    ligase    /    DNA ligase 1
DTO Classes
protein    /    Enzyme    /    Ligase    /    DNA ligase    /    DNA ligase 1

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityspeciesApplicationView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDisease TypeMondoid

      Pathway

      Data SourceNameExplore more targetsExplore in Source