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NUCB1

DescriptionNucleobindin-1

Gene and Protein Information

Gene ID4924
Uniprot Accession IDs B2RD64 Q15838 Q7Z4J7 Q9BUR1
Ensembl ID ENSP00000385923
Symbol NUC NUC CALNUC
FamilyBelongs to the nucleobindin family.
Sequence
MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Mouse18220Nucb1nucleobindin 110090MGI:97388Inparanoid, OMA
Rat84595Nucb1nucleobindin 110116RGD:620030Inparanoid, OMA
Dog484391NUCB1nucleobindin 19615VGNC:53746Inparanoid, OMA
Cow505351NUCB1nucleobindin 19913VGNC:32318Inparanoid, OMA
Pig100512538NUCB1nucleobindin 19823Inparanoid, OMA
Opossum100030394NUCB1nucleobindin 113616Inparanoid, OMA
Anole lizard100563295nucb1nucleobindin 128377Inparanoid, OMA
Xenopus407884nucb1nucleobindin 18364XB-GENE-478104Inparanoid, OMA
C. elegans181230nucb-1NUCleoBindin homolog6239Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    calcium-binding protein    /    calmodulin    /    Nucleobindin-1
protein    /    calcium-binding protein    /    annexin    /    Nucleobindin-1
protein    /    calcium-binding protein    /    nucleic acid binding    /    Nucleobindin-1
DTO Classes
protein    /    Calcium-binding protein    /    Intracellular calcium-sensing protein    /    Calmodulin    /    Nucleobindin-1

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      astrocytoma3773Expression AtlasMONDO:0021636
      atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
      COPD393Expression AtlasMONDO:0005002
      dermatomyositis987Expression AtlasMONDO:0016367
      diabetes mellitus1167Expression AtlasMONDO:0005015
      ependymoma5607Expression AtlasMONDO:0021191
      glioblastoma5998Expression AtlasMONDO:0018177
      group 3 medulloblastoma7142Expression AtlasMONDO:0007959
      pancreatic ductal adenocarcinoma liver metastasis3122Expression AtlasMONDO:0005184
      psoriasis6696Expression AtlasMONDO:0005083

      Bibliography

      1.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      2.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039]
      3.Miura, K K, Titani, K K, Kurosawa, Y Y and Kanai, Y Y. 1992-08-31 Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure. [PMID:1520323]
      4.de Alba, Eva E and Tjandra, Nico N. 2004-08-10 Structural studies on the Ca2+-binding domain of human nucleobindin (calnuc). [PMID:15287731]
      5.Breuza, Lionel L and 6 more authors. 2004-11-05 Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. [PMID:15308636]
      6.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334]
      7.Palmer, David J DJ and 5 more authors. 2006-04 Human colostrum: identification of minor proteins in the aqueous phase by proteomics. [PMID:16502470]
      8.Chen, Yao Y and 6 more authors. 2007-05 Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection. [PMID:17390015]
      9.Tsukumo, Yoshinori Y and 6 more authors. 2007-10-05 Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation. [PMID:17686766]
      10.Barbe, Laurent L and 10 more authors. 2008-03 Toward a confocal subcellular atlas of the human proteome. [PMID:18029348]