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PPIA

DescriptionPeptidyl-prolyl cis-trans isomerase A

Gene and Protein Information

Gene ID5478
Uniprot Accession IDs A8K220 P05092 Q3KQW3 Q567Q0 Q6IBU5 Q96IX3 Q9BRU4 Q9BTY9 Q9UC61 PPIase A
Ensembl ID ENSP00000419425
Symbol CYPA CYPA CYPH HEL-S-69p
FamilyBelongs to the cyclophilin-type PPIase family. PPIase A subfamily.
Sequence
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Macaque574102PPIApeptidylprolyl isomerase A9544Inparanoid, OMA, EggNOG
Mouse268373Ppiapeptidylprolyl isomerase A10090MGI:97749Inparanoid, OMA, EggNOG
Rat25518Ppiapeptidylprolyl isomerase A10116RGD:3372Inparanoid, OMA
Dog403581LOC403581peptidylprolyl isomerase A (cyclophilin A) pseudogene9615OMA, EggNOG
Cow281418PPIApeptidylprolyl isomerase A9913Inparanoid, OMA, EggNOG
Pig397637PPIApeptidylprolyl isomerase A9823Inparanoid, OMA, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details
Recombinant Human Cyclophilin A ProteinE. coliN-His
Out of Stock
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Recombinant Human Cyclophilin A ProteinE. coliN-His & SUMO
Out of Stock
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Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
Cyclophilin A Mouse mAbHuman
  • IF/ICC
  • IHC
  • WB
Out of Stock
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Associated Approved Drugs

  1. ciclosporinTetrahydrouridine

    RETTclinnull

    MODULATOR pIC50: 8.04

Associated Active Ligands

    Associated Diseases

    NameDirect Associated TargetsDisease TypeMondoid
    acute quadriplegic myopathy1255Expression AtlasMONDO:0005336
    breast cancer3880Expression AtlasMONDO:0007254
    intraductal papillary-mucinous adenoma (IPMA)2987Expression AtlasMONDO:0004381
    intraductal papillary-mucinous carcinoma (IPMC)3017Expression AtlasMONDO:0004285
    juvenile dermatomyositis1263Expression AtlasMONDO:0008054
    osteosarcoma7970Expression AtlasMONDO:0009807
    ovarian cancer8576Expression AtlasMONDO:0008170
    Carcinoma, Non-Small-Cell Lung3141CTDMONDO:0005233
    Carcinoma, Squamous Cell125CTDMONDO:0005096
    Mouth Neoplasms0CTD

    Pathway

    Data SourceNameExplore more targetsExplore in Source
    KEGGNecroptosis151 Targetspath:hsa04217