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IDO1

DescriptionIndoleamine 2,3-dioxygenase 1

Gene and Protein Information

Gene ID3620
Uniprot Accession IDs E5RGR8 F6M9T7 Q540B4 IDO-1
Ensembl ID ENSP00000430950
Symbol IDO INDO IDO INDO IDO-1
FamilyBelongs to the indoleamine 2,3-dioxygenase family.
Sequence
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp464134IDO1indoleamine 2,3-dioxygenase 19598VGNC:3011OMA, EggNOG
Macaque574370IDO1indoleamine 2,3-dioxygenase 19544OMA, EggNOG
Mouse15930Ido1indoleamine 2,3-dioxygenase 110090MGI:96416Inparanoid, OMA, EggNOG
Rat66029Ido1indoleamine 2,3-dioxygenase 110116RGD:619989Inparanoid, OMA, EggNOG
Dog475574IDO1indoleamine 2,3-dioxygenase 19615VGNC:41865Inparanoid, OMA, EggNOG
Horse106782641IDO1indoleamine 2,3-dioxygenase 19796VGNC:18938Inparanoid, OMA, EggNOG
Cow506281IDO1indoleamine 2,3-dioxygenase 19913VGNC:30035Inparanoid, OMA, EggNOG
Pig100519877IDO1indoleamine 2,3-dioxygenase 19823Inparanoid, OMA, EggNOG
Opossum100032999IDO1indoleamine 2,3-dioxygenase 113616Inparanoid, EggNOG
S.cerevisiae853541BNA2dioxygenase BNA24932S000003839Inparanoid, OMA, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      active Crohn's disease1059Expression AtlasMONDO:0005011
      breast cancer3880Expression AtlasMONDO:0007254
      cutaneous lupus erythematosus1094Expression AtlasMONDO:0005282
      cystic fibrosis1831Expression AtlasMONDO:0009061
      head and neck cancer501Expression AtlasMONDO:0005627
      interstitial cystitis2307Expression AtlasMONDO:0018301
      invasive ductal carcinoma2965Expression AtlasMONDO:0004953
      juvenile dermatomyositis1263Expression AtlasMONDO:0008054
      lung cancer4468Expression AtlasMONDO:0008903
      lung carcinoma2913Expression AtlasMONDO:0005138

      Bibliography

      1.Dias Neto, E E and 23 more authors. 2000-03-28 Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. [PMID:10737800]
      2.Takikawa, O O, Littlejohn, T K TK and Truscott, R J RJ. 2001-03 Indoleamine 2,3-dioxygenase in the human lens, the first enzyme in the synthesis of UV filters. [PMID:11180976]
      3.Kudo, Y Y and Boyd, C A CA. 2001-03-01 The role of L-tryptophan transport in L-tryptophan degradation by indoleamine 2,3-dioxygenase in human placental explants. [PMID:11230514]
      4.Terentis, Andrew C AC and 7 more authors. 2002-05-03 The heme environment of recombinant human indoleamine 2,3-dioxygenase. Structural properties and substrate-ligand interactions. [PMID:11867636]
      5.Kvirkvelia, N N and 10 more authors. 2002-02 Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells. [PMID:11876748]
      6.Sedlmayr, P P and 9 more authors. 2002-04 Localization of indoleamine 2,3-dioxygenase in human female reproductive organs and the placenta. [PMID:11912287]
      7.Barceló-Batllori, Sílvia S and 7 more authors. 2002-05 Proteomic analysis of cytokine induced proteins in human intestinal epithelial cells: implications for inflammatory bowel diseases. [PMID:11987129]
      8.Terness, Peter P and 6 more authors. 2002-08-19 Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. [PMID:12186837]
      9.Munn, David H DH and 11 more authors. 2002-09-13 Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. [PMID:12228717]
      10.Mirani, Marco M and 5 more authors. 2002-12-01 HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection. [PMID:12444143]