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PRKAR1B

DescriptioncAMP-dependent protein kinase type I-beta regulatory subunit

Gene and Protein Information

Gene ID5575
Uniprot Accession IDs Q8N422
Ensembl ID ENSP00000385749
Symbol PRKAR1
FamilyBelongs to the cAMP-dependent kinase regulatory chain family.
Sequence
MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFISLTV
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Mouse19085Prkar1bprotein kinase, cAMP dependent regulatory, type I beta10090MGI:97759Inparanoid, OMA, EggNOG
Rat25521Prkar1bprotein kinase cAMP-dependent type 1 regulatory subunit beta10116RGD:3392Inparanoid, OMA
Dog480805PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta9615VGNC:44975Inparanoid, OMA
OpossumPRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta [Source:HGNC Symbol;Acc:HGNC:9390]13616Inparanoid, OMA
Chicken416446PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta9031CGNC:2686Inparanoid, OMA
Anole lizard100557976prkar1bprotein kinase cAMP-dependent type I regulatory subunit beta28377Inparanoid, OMA
Xenopus594933prkar1aprotein kinase cAMP-dependent type I regulatory subunit alpha8364XB-GENE-856481OMA, EggNOG
Zebrafish767685prkar1bprotein kinase, cAMP-dependent, regulatory, type I, beta7955ZDB-GENE-060929-580Inparanoid, OMA
C. elegans180864kin-2cAMP-dependent protein kinase regulatory subunit6239OMA, EggNOG
S.cerevisiae854778BCY1cAMP-dependent protein kinase regulatory subunit BCY14932S000001295OMA, EggNOG

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

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      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Laxminarayana, D D and 5 more authors. 1999-05-01 Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes. [PMID:10228048]
      2.Adachi, Megumi M and Lewis, Elaine J EJ. 2002-06-21 The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status. [PMID:11943777]
      3.Oliver, Carey J CJ and 7 more authors. 2002-07 Targeting protein phosphatase 1 (PP1) to the actin cytoskeleton: the neurabin I/PP1 complex regulates cell morphology. [PMID:12052877]
      4.Nguyen, Duy T DT, Rovira, Ilsa I II and Finkel, Toren T. 2002-06-19 Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A. [PMID:12067711]
      5.Mucignat-Caretta, C C and Caretta, A A. 2001-11 Localization of Triton-insoluble cAMP-dependent kinase type RIbeta in rat and mouse brain. [PMID:12373096]
      6.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      7.Jiang, Guoqiang G and Zhang, Bei B BB. 2003-04 Glucagon and regulation of glucose metabolism. [PMID:12626323]
      8.Carlson, Cathrine R CR, Ruppelt, Anja A and Taskén, Kjetil K. 2003-03-28 A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system. [PMID:12634056]
      9.Solberg, R R and 7 more authors. 1992-09 Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7. [PMID:1358799]
      10.Zhang, Lizhi L and 6 more authors. 2004-03 A transforming growth factor beta-induced Smad3/Smad4 complex directly activates protein kinase A. [PMID:14966294]