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KDM4A

DescriptionLysine-specific demethylase 4A

Gene and Protein Information

Gene ID9682
Uniprot Accession IDs Q5VVB1
Ensembl ID ENSP00000361473
Symbol JHDM3A JMJD2 JMJD2A KIAA0677 JMJD2 JHDM3A JMJD2A TDRD14A
FamilyBelongs to the JHDM3 histone demethylase family.
Sequence
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELPPRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDGLTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTGVLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDINLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp456829KDM4Alysine demethylase 4A9598VGNC:8061Inparanoid, OMA
Macaque701272KDM4Alysine demethylase 4A9544OMA, EggNOG
Mouse230674Kdm4alysine (K)-specific demethylase 4A10090MGI:2446210Inparanoid, OMA, EggNOG
Rat313539Kdm4alysine demethylase 4A10116RGD:1306378Inparanoid, OMA, EggNOG
Dog482530KDM4Alysine demethylase 4A9615VGNC:42324Inparanoid, OMA, EggNOG
Horse100053154KDM4Alysine demethylase 4A9796VGNC:19337Inparanoid, OMA, EggNOG
Cow512622KDM4Alysine demethylase 4A9913VGNC:30527Inparanoid, OMA, EggNOG
Platypus100077720KDM4Alysine demethylase 4A9258Inparanoid, OMA
Chicken424571KDM4Alysine demethylase 4A9031CGNC:7658Inparanoid, OMA
Anole lizard100566487kdm4alysine demethylase 4A28377Inparanoid, OMA
Xenopus100135350kdm4alysine (K)-specific demethylase 4A8364XB-GENE-1010381Inparanoid, OMA

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      group 3 medulloblastoma7142Expression AtlasMONDO:0007959
      intraductal papillary-mucinous adenoma (IPMA)2987Expression AtlasMONDO:0004381
      intraductal papillary-mucinous carcinoma (IPMC)3017Expression AtlasMONDO:0004285
      osteosarcoma7970Expression AtlasMONDO:0009807
      Autism spectrum disorder0JensenLab Experiment TIGA
      Attention deficit hyperactivity disorder0JensenLab Experiment TIGA
      Endogenous depression0JensenLab Experiment TIGA
      Bipolar disorder0JensenLab Experiment TIGA

      Bibliography

      1.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      2.Katoh, Masuko M and Katoh, Masaru M. 2004-06 Identification and characterization of JMJD2 family genes in silico. [PMID:15138608]
      3.Brandenberger, Ralph R and 13 more authors. 2004-06 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. [PMID:15146197]
      4.Suzuki, Yutaka Y and 7 more authors. 2004-09 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. [PMID:15342556]
      5.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334]
      6.Gray, Steven G SG and 10 more authors. 2005-08-05 Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. [PMID:15927959]
      7.Zhang, Dianzheng D, Yoon, Ho-Guen HG and Wong, Jiemin J. 2005-08 JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). [PMID:16024779]
      8.Tao, W Andy WA and 8 more authors. 2005-08 Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. [PMID:16094384]
      9.Kim, Jeesun J and 7 more authors. 2006-04 Tudor, MBT and chromo domains gauge the degree of lysine methylation. [PMID:16415788]
      10.Huang, Ying Y, Fang, Jia J, Bedford, Mark T MT, Zhang, Yi Y and Xu, Rui-Ming RM. 2006-05-05 Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. [PMID:16601153]