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NPC1L1
| Description | NPC1-like intracellular cholesterol transporter 1 |
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Gene and Protein Information
| Gene ID | 29881 |
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| Uniprot Accession IDs | A4D2J7 B7ZLE6 D3DVK9 Q17RV5 Q6R3Q4 Q9UHC8 |
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| Ensembl ID | ENSP00000289547 |
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| Symbol | LDLCQ7 NPC11L1 SLC65A2 |
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| Family | Belongs to the patched family. |
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| Sequence | MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQALDSTFYLGQMPGSLVLIIILCSVFAVVTILLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAHCNLYLLDSTSRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKGAGAISNFLPNNGRQF Show more |
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Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
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| Chimp | 463381 | NPC1L1 | NPC1 like intracellular cholesterol transporter 1 | 9598 | VGNC:8703 | OMA, EggNOG |
| Macaque | 699235 | NPC1L1 | NPC1 like intracellular cholesterol transporter 1 | 9544 | | Inparanoid, OMA, EggNOG |
| Mouse | 237636 | Npc1l1 | NPC1 like intracellular cholesterol transporter 1 | 10090 | MGI:2685089 | Inparanoid, OMA, EggNOG |
| Rat | 432367 | Npc1l1 | NPC1 like intracellular cholesterol transporter 1 | 10116 | RGD:1303135 | Inparanoid, OMA, EggNOG |
| Horse | 100065105 | NPC1L1 | NPC1 like intracellular cholesterol transporter 1 | 9796 | VGNC:20832 | Inparanoid, OMA, EggNOG |
| Cow | 539550 | NPC1L1 | NPC1 like intracellular cholesterol transporter 1 | 9913 | VGNC:32195 | Inparanoid, OMA, EggNOG |
| Pig | 100515982 | NPC1L1 | NPC1 like intracellular cholesterol transporter 1 | 9823 | | Inparanoid, OMA, EggNOG |
| Opossum | 100030165 | NPC1L1 | NPC1 like intracellular cholesterol transporter 1 | 13616 | | Inparanoid, EggNOG |
| Platypus | | NPC1L1 | NPC1 like intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7898] | 9258 | | OMA, EggNOG |
| Xenopus | 100487339 | npc1l1 | NPC1 like 1 | 8364 | XB-GENE-964011 | Inparanoid, OMA, EggNOG |
| C. elegans | 180719 | ncr-1 | Niemann-Pick C1 protein homolog 1 | 6239 | | Inparanoid, OMA |
| S.cerevisiae | 856101 | NCR1 | sphingolipid transporter | 4932 | S000005927 | Inparanoid, OMA |
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Activity | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | species | Application | View Details |
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Associated Approved Drugs
Associated Active Ligands
Pathway
| Data Source | Name | Explore more targets | Explore in Source |
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