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NOTCH1

DescriptionNeurogenic locus notch homolog protein 1

Gene and Protein Information

Gene ID4851
Uniprot Accession IDs Q59ED8 Q5SXM3 Notch 1
Ensembl ID ENSP00000277541
Symbol TAN1 hN1 AOS5 TAN1 AOVD1
FamilyBelongs to the NOTCH family.
Sequence
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYYGREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSETVEPPPPAQLHFMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNASDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLDDQTDHRQWTQQHLDAADLRMSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNREETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNLVRSPQLHGAPLGGTPTLSPPLCSPNGYLGSLKPGVQGKKVRKPSSKGLACGSKEAKDLKARRKKSQDGKGCLLDSSGMLSPVDSLESPHGYLSDVASPPLLPSPFQQSPSVPLNHLPGMPDTHLGIGHLNVAAKPEMAALGGGGRLAFETGPPRLSHLPVASGTSTVLGSSSGGALNFTVGGSTSLNGQCEWLSRLQSGMVPNQYNPLRGSVAPGPLSTQAPSLQHGMVGPLHSSLAASALSQMMSYQGLPSTRLATQPHLVQTQQVQPQNLQMQQQNLQPANIQQQQSLQPPPPPPQPHLGVSSAASGHLGRSFLSGEPSQADVQPLGPSSLAVHTILPQESPALPTSLPSSLVPPVTAAQFLTPPSQHSYSSPVDNTPSHQLQVPEHPFLTPSPESPDQWSSSSPHSNVSDWSEGVSSPPTSMQSQIARIPEAFK
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp464865NOTCH1notch 19598VGNC:4807OMA, EggNOG
Mouse18128Notch1notch 110090MGI:97363Inparanoid, OMA, EggNOG
Rat25496Notch1notch 110116RGD:3187Inparanoid, OMA, EggNOG
Dog480676NOTCH1notch 19615VGNC:43898Inparanoid, OMA, EggNOG
Horse100068764NOTCH1notch 19796VGNC:20817Inparanoid, OMA, EggNOG
Cow767866NOTCH1notch 19913VGNC:32177Inparanoid, OMA, EggNOG
Opossum100616999NOTCH1notch 113616Inparanoid, EggNOG
Xenopus100037842notch1notch 18364XB-GENE-479318Inparanoid, OMA

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details
Recombinant Human Notch-1 ProteinE. coliN-His
Out of Stock
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Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
Brontictuzumab (anti-NOTCH1)Human,Mouse
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
In stock
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NOTCH1 AntibodyHuman,Mouse,Rat
  • IF/ICC
  • IHC
  • WB
Out of Stock
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Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      Aortic valve disease 14UniProt DiseaseMONDO:0024523
      Adams-Oliver syndrome 51UniProt DiseaseMONDO:0014459
      Aortic valve disorder4MonarchMONDO:0024523
      Adams-Oliver Syndrome 16MonarchMONDO:0024506
      Tetralogy of Fallot22MonarchMONDO:0008542
      Adams-Oliver Syndrome 51MonarchMONDO:0014459
      Heart, malformation of3MonarchMONDO:0009327
      astrocytic glioma3773Expression AtlasMONDO:0021636
      Astrocytoma, Pilocytic3186Expression AtlasMONDO:0016691
      ependymoma5607Expression AtlasMONDO:0021191

      Bibliography

      1.Ray, W J WJ and 7 more authors. 1999-03-16 Evidence for a physical interaction between presenilin and Notch. [PMID:10077672]
      2.Gray, G E GE and 9 more authors. 1999-03 Human ligands of the Notch receptor. [PMID:10079256]
      3.Wilson-Rawls, J J, Molkentin, J D JD, Black, B L BL and Olson, E N EN. 1999-04 Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. [PMID:10082551]
      4.De Strooper, B B and 11 more authors. 1999-04-08 A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. [PMID:10206645]
      5.Artavanis-Tsakonas, S S, Rand, M D MD and Lake, R J RJ. 1999-04-30 Notch signaling: cell fate control and signal integration in development. [PMID:10221902]
      6.Callahan, J J, Aster, J J, Sklar, J J, Kieff, E E and Robertson, E S ES. 2000-01 Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells. [PMID:10637481]
      7.Rand, M D MD and 6 more authors. 2000-03 Calcium depletion dissociates and activates heterodimeric notch receptors. [PMID:10669757]
      8.Zhou, S S and 6 more authors. 2000-04 SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. [PMID:10713164]
      9.Kurooka, H H and Honjo, T T. 2000-06-02 Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. [PMID:10747963]
      10.Shutter, J R JR and 7 more authors. 2000-06-01 Dll4, a novel Notch ligand expressed in arterial endothelium. [PMID:10837024]