MTOR

Description	Serine/threonine-protein kinase mTOR

Gene and Protein Information

Gene ID	2475
Uniprot Accession IDs	Q4LE76 Q5TER1 Q6LE87 Q96QG3 Q9Y4I3
Ensembl ID	ENSP00000354558
Symbol	FRAP FRAP1 FRAP2 RAFT1 RAPT1 SKS FRAP FRAP1 FRAP2 RAFT1 RAPT1
Family	Belongs to the PI3/PI4-kinase family.
Sequence	MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	457945	MTOR	mechanistic target of rapamycin kinase	9598	VGNC:8416	OMA, EggNOG
Macaque	106992736	MTOR	mechanistic target of rapamycin kinase	9544		OMA, EggNOG
Mouse	56717	Mtor	mechanistic target of rapamycin kinase	10090	MGI:1928394	Inparanoid, OMA, EggNOG
Rat	56718	Mtor	mechanistic target of rapamycin kinase	10116	RGD:68371	Inparanoid, OMA, EggNOG
Dog	478232	MTOR	mechanistic target of rapamycin kinase	9615	VGNC:43490	Inparanoid, OMA, EggNOG
Horse	100051341	MTOR	mechanistic target of rapamycin kinase	9796	VGNC:20434	Inparanoid, OMA, EggNOG
Cow	100139219	MTOR	mechanistic target of rapamycin kinase	9913	VGNC:31748	Inparanoid, OMA, EggNOG
Pig	100127359	MTOR	mechanistic target of rapamycin kinase	9823		Inparanoid, OMA, EggNOG
Opossum	100619675	MTOR	mechanistic target of rapamycin kinase	13616		Inparanoid, OMA, EggNOG
Chicken	419455	MTOR	mechanistic target of rapamycin	9031	CGNC:2430	Inparanoid, OMA, EggNOG
Anole lizard	100565267	mtor	mechanistic target of rapamycin kinase	28377		Inparanoid, OMA, EggNOG
Xenopus		XB-GENE-994583	Putative ortholog of fKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (MTOR), 1 of 2 [Source:Xenbase;Acc:XB-GENE-994583]	8364		OMA, EggNOG
Zebrafish	324254	mtor	mechanistic target of rapamycin kinase	7955	ZDB-GENE-030131-2974	Inparanoid, OMA, EggNOG
C. elegans	172167	let-363	Target of rapamycin homolog	6239		Inparanoid, OMA
Fruitfly	47396	Tor	Target of rapamycin	7227	FBgn0021796	Inparanoid, EggNOG
S.cerevisiae	853632	TOR2	phosphatidylinositol kinase-related protein kinase TOR2	4932	S000001686	Inparanoid, OMA
S.cerevisiae	853529	TOR1	phosphatidylinositol kinase-related protein kinase TOR1	4932	S000003827	OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    non-receptor serine/threonine protein kinase    /    Serine/threonine-protein kinase mtor
protein    /    protein kinase    /    Serine/threonine-protein kinase mtor
protein    /    nucleotide kinase    /    Serine/threonine-protein kinase mtor
protein    /    transferase    /    Serine/threonine-protein kinase mtor
protein    /    kinase    /    Serine/threonine-protein kinase mtor
protein    /    nucleic acid binding    /    Serine/threonine-protein kinase mtor

DTO Classes
protein / Kinase / Protein kinase / Atypical group / PIKK family / FRAP subfamily / Serine/threonine-protein kinase mtor

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Associated Antibodies

Name	Specifications	Species reactivity	species	Application	View Details

Related active small molecules

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Disease Type	Mondoid

Pathway

Data Source	Name	Explore more targets	Explore in Source