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DAGLB

DescriptionSn1-specific diacylglycerol lipase beta

Gene and Protein Information

Gene ID221955
Uniprot Accession IDs Q8NCG7 A4D2P3 B3KV90 B4DQU0 Q6PIX3 Q8N2N2 Q8N9S1 Q8TED3 Q8WXE6 DGL-beta
Ensembl ID ENSP00000297056
Symbol KCCR13L DAGLBETA
FamilyBelongs to the AB hydrolase superfamily. Lipase family.
Sequence
MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLIVLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVADGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQLLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLALLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPLTGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLVALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLINDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQEYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNPNNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQEEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVSCPAQGVSSVDVA
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Macaque717799DAGLBdiacylglycerol lipase beta9544OMA, EggNOG
Mouse231871Daglbdiacylglycerol lipase, beta10090MGI:2442032Inparanoid, OMA, EggNOG
Rat304289Daglbdiacylglycerol lipase, beta10116RGD:1310193Inparanoid, OMA, EggNOG
Dog479756DAGLBdiacylglycerol lipase beta9615VGNC:39765Inparanoid, OMA, EggNOG
Horse100061701DAGLBdiacylglycerol lipase beta9796VGNC:17002Inparanoid, OMA, EggNOG
Cow538021DAGLBdiacylglycerol lipase beta9913VGNC:27873Inparanoid, OMA, EggNOG
Pig100627176DAGLBdiacylglycerol lipase beta9823OMA, EggNOG
Opossum100020183DAGLBdiacylglycerol lipase beta13616Inparanoid, OMA, EggNOG
Platypus100076677DAGLBdiacylglycerol lipase beta9258Inparanoid, OMA, EggNOG
Chicken416625DAGLBdiacylglycerol lipase beta9031CGNC:5377Inparanoid, OMA
XenopusDAGLBdiacylglycerol lipase beta [Source:HGNC Symbol;Acc:HGNC:28923]8364OMA, EggNOG
Zebrafish565287daglbdiacylglycerol lipase, beta7955ZDB-GENE-070619-2Inparanoid, OMA, EggNOG
C. elegans3565075dagl-2DiAcylGlycerol Lipase homolog6239OMA, EggNOG

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      aldosterone-producing adenoma698Expression AtlasMONDO:0004972
      gastric carcinoma1287Expression AtlasMONDO:0004950
      medulloblastoma, large-cell6269Expression AtlasMONDO:0002791
      osteosarcoma7970Expression AtlasMONDO:0009807
      primary pancreatic ductal adenocarcinoma3122Expression AtlasMONDO:0005184
      Inflammatory bowel disease0JensenLab Experiment TIGA
      Heart disease0JensenLab Experiment TIGA
      Obesity0DrugCentral Indication

      Bibliography

      1.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      2.Scherer, Stephen W SW and 89 more authors. 2003-05-02 Human chromosome 7: DNA sequence and biology. [PMID:12690205]
      3.Bisogno, Tiziana T and 13 more authors. 2003-11-10 Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. [PMID:14610053]
      4.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039]
      5.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334]
      6.Otsuki, Tetsuji T and 24 more authors. 2005 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. [PMID:16303743]
      7.Girard, Angélique A, Sachidanandam, Ravi R, Hannon, Gregory J GJ and Carmell, Michelle A MA. 2006-07-13 A germline-specific class of small RNAs binds mammalian Piwi proteins. [PMID:16751776]
      8.Ma, Jun J, Dempsey, Adam A AA, Stamatiou, Dimitri D, Marshall, K Wayne KW and Liew, Choong-Chin CC. 2007-03 Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. [PMID:16806233]
      9.Schröder, Bernd B and 8 more authors. 2007-12 Integral and associated lysosomal membrane proteins. [PMID:17897319]
      10.Gaudet, Pascale P, Livstone, Michael S MS, Lewis, Suzanna E SE and Thomas, Paul D PD. 2011-09 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. [PMID:21873635]