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DAGLA

DescriptionSn1-specific diacylglycerol lipase alpha

Gene and Protein Information

Gene ID747
Uniprot Accession IDs Q9Y4D2 A7E233 Q6WQJ0 DGL-alpha
Ensembl ID ENSP00000257215
Symbol C11orf11 KIAA0659 NSDDR NSDDR C11orf11 DAGLALPHA DAGL(ALPHA)
FamilyBelongs to the AB hydrolase superfamily. Lipase family.
Sequence
MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFALAAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRNSSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIRTSTPTGHGASPAKQDELVISAR
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp451241DAGLAdiacylglycerol lipase alpha9598VGNC:11335Inparanoid, OMA, EggNOG
Mouse269060Dagladiacylglycerol lipase, alpha10090MGI:2677061Inparanoid, OMA, EggNOG
Rat309207Dagladiacylglycerol lipase, alpha10116RGD:1359461Inparanoid, OMA, EggNOG
Dog483795DAGLAdiacylglycerol lipase alpha9615VGNC:39764Inparanoid, OMA, EggNOG
Horse100059772DAGLAdiacylglycerol lipase alpha9796VGNC:17001Inparanoid, OMA, EggNOG
Cow523665DAGLAdiacylglycerol lipase alpha9913VGNC:27872Inparanoid, OMA, EggNOG
Pig100520824DAGLAdiacylglycerol lipase alpha9823Inparanoid, OMA, EggNOG
Anole lizard103279659dagladiacylglycerol lipase alpha28377Inparanoid, OMA, EggNOG
Xenopusdagladiacylglycerol lipase, alpha [Source:Xenbase;Acc:XB-GENE-6037909]8364OMA, EggNOG
Zebrafish569398dagladiacylglycerol lipase, alpha7955ZDB-GENE-070619-1OMA, EggNOG

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      Spinocerebellar ataxia 200UniProt Disease
      lung carcinoma2913Expression AtlasMONDO:0005138
      autosomal dominant cerebellar ataxia50eRAMMONDO:0020380
      hereditary ataxia36eRAMMONDO:0100309
      Neurodegenerative disease0JensenLab Knowledge UniProtKB-KW
      Autosomal dominant cerebellar ataxia0JensenLab Knowledge UniProtKB-KW
      Inflammatory bowel disease0JensenLab Experiment TIGA
      Colorectal adenoma0JensenLab Experiment TIGA
      Gallbladder disease0JensenLab Experiment TIGA
      Bipolar I disorder0JensenLab Experiment TIGA

      Bibliography

      1.Nakajima, Daisuke D and 5 more authors. 2002-06-30 Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. [PMID:12168954]
      2.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      3.Bisogno, Tiziana T and 13 more authors. 2003-11-10 Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. [PMID:14610053]
      4.Jung, Kwang-Mook KM and 7 more authors. 2005-11 Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. [PMID:16051747]
      5.Knight, Melanie A MA and 12 more authors. 2008-12-15 A duplication at chromosome 11q12.2-11q12.3 is associated with spinocerebellar ataxia type 20. [PMID:18801880]
      6.Lemaitre, Rozenn N RN and 34 more authors. 2011-07 Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. [PMID:21829377]
      7.Gaudet, Pascale P, Livstone, Michael S MS, Lewis, Suzanna E SE and Thomas, Paul D PD. 2011-09 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. [PMID:21873635]
      8.Kennedy, Richard B RB and 5 more authors. 2012-09 Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. [PMID:22610502]
      9.Long, Leonora E LE, Lind, Jonna J, Webster, Maree M and Weickert, Cynthia Shannon CS. 2012-07-24 Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex. [PMID:22827915]
      10.García del Caño, Gontzal G and 6 more authors. 2014-01 Nuclear phospholipase C-β1 and diacylglycerol LIPASE-α in brain cortical neurons. [PMID:24076015]