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GABRA6

DescriptionGamma-aminobutyric acid receptor subunit alpha-6

Gene and Protein Information

Gene ID2559
Uniprot Accession IDs A8K096 Q4VAV2
Ensembl ID ENSP00000274545
FamilyBelongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily.
Sequence
MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp471725GABRA6gamma-aminobutyric acid type A receptor alpha6 subunit9598VGNC:8619OMA, EggNOG
Macaque697010GABRA6gamma-aminobutyric acid type A receptor alpha6 subunit9544Inparanoid, OMA, EggNOG
Mouse14399Gabra6gamma-aminobutyric acid (GABA) A receptor, subunit alpha 610090MGI:95618Inparanoid, OMA, EggNOG
Rat29708Gabra6gamma-aminobutyric acid type A receptor alpha 6 subunit10116RGD:61861Inparanoid, OMA, EggNOG
Dog489145GABRA6gamma-aminobutyric acid type A receptor alpha6 subunit9615VGNC:51895Inparanoid, OMA, EggNOG
Horse100070890GABRA6gamma-aminobutyric acid type A receptor alpha6 subunit9796VGNC:18196Inparanoid, OMA, EggNOG
Cow539194GABRA6gamma-aminobutyric acid type A receptor alpha6 subunit9913VGNC:29195Inparanoid, OMA, EggNOG
Pig100516885GABRA6gamma-aminobutyric acid type A receptor alpha6 subunit9823OMA, EggNOG
Opossum100030493GABRA6gamma-aminobutyric acid type A receptor alpha6 subunit13616Inparanoid, EggNOG
Platypus100074052GABRA6gamma-aminobutyric acid type A receptor alpha6 subunit9258Inparanoid, EggNOG
Chicken395931GABRA6gamma-aminobutyric acid type A receptor alpha6 subunit9031CGNC:1184Inparanoid, OMA, EggNOG
Anole lizard100556488gabra6gamma-aminobutyric acid type A receptor alpha6 subunit28377Inparanoid, OMA, EggNOG
Xenopusgabra6gamma-aminobutyric acid (GABA) A receptor, alpha 6 [Source:Xenbase;Acc:XB-GENE-6049732]8364OMA, EggNOG
Zebrafish559693gabra6bgamma-aminobutyric acid (GABA) A receptor, alpha 6b7955ZDB-GENE-080815-1OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    transporter    /    ligand-gated ion channel    /    Gamma-aminobutyric acid receptor subunit alpha-6
protein    /    transporter    /    ion channel    /    Gamma-aminobutyric acid receptor subunit alpha-6
protein    /    transporter    /    acetylcholine receptor    /    Gamma-aminobutyric acid receptor subunit alpha-6
protein    /    transporter    /    GABA receptor    /    Gamma-aminobutyric acid receptor subunit alpha-6
protein    /    transporter    /    receptor    /    Gamma-aminobutyric acid receptor subunit alpha-6
DTO Classes
protein    /    Ion channel    /    Neurotransmitter receptor, Cys loop, ligand-gated ion channel (LIC) family    /    Gamma-aminobutyric acid receptor subfamily    /    GABRA6 sub-subfamily    /    Gamma-aminobutyric acid receptor subunit alpha-6

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      ependymoma5607Expression AtlasMONDO:0021191
      subependymal giant cell astrocytoma2343Expression AtlasMONDO:0016693
      Infarction, Middle Cerebral Artery34CTDMONDO:0006857
      Schizophrenia1087CTDMONDO:0005090
      Alcoholic Intoxication, Chronic0DisGeNET
      Mental Depression0DisGeNET
      Depressive disorder292DisGeNETMONDO:0002050
      Schizophrenia1087DisGeNETMONDO:0005090
      Middle Cerebral Artery Syndrome0DisGeNET
      Mood Disorders0DisGeNET

      Bibliography

      1. and Russek, S J SJ. 1999-02-18 Evolution of GABA(A) receptor diversity in the human genome. [PMID:10023064]
      2.Comings, D E DE and 9 more authors. 2000-11 A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. [PMID:11140838]
      3.Rosmond, Roland R, Bouchard, Claude C and Björntorp, Per P. 2002-06 Association between a variant at the GABA(A)alpha6 receptor subunit gene, abdominal obesity, and cortisol secretion. [PMID:12079890]
      4.Rosmond, R R, Bouchard, C C and Björntorp, P P. 2002-07 Allelic variants in the GABA(A)alpha6 receptor subunit gene (GABRA6) is associated with abdominal obesity and cortisol secretion. [PMID:12080446]
      5.Chang, Y T YT and 8 more authors. 2002 Association of the gamma-aminobutyric acid A receptor gene cluster with alcohol dependence in Taiwanese Han. [PMID:12232773]
      6.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      7.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039]
      8.Sen, Srijan S and 7 more authors. 2004-02-01 Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. [PMID:14744464]
      9.Peran, Macarena M, Hooper, Helen H, Rayner, Sharon L SL, Stephenson, F Anne FA and Salas, Ramiro R. 2004-07-01 GABAA receptor alpha1 and alpha6 subunits mediate cell surface anchoring in cultured cells. [PMID:15196679]
      10.Uhart, M M, McCaul, M E ME, Oswald, L M LM, Choi, L L and Wand, G S GS. 2004-11 GABRA6 gene polymorphism and an attenuated stress response. [PMID:15197399]