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CYP2C19

DescriptionCytochrome P450 2C19

Gene and Protein Information

Gene ID1557
Uniprot Accession IDs P33259 Q8WZB1 Q8WZB2 Q9UCD4
Ensembl ID ENSP00000360372
Symbol CPCJ CYP2C P450C2C CYPIIC17 CYPIIC19 P450IIC19
FamilyBelongs to the cytochrome P450 family.
Sequence
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Rat499353Cyp2c24cytochrome P450, family 2, subfamily c, polypeptide 2410116RGD:1563697Inparanoid, OMA
Cow535243CYP2C18cytochrome P450, family 2, subfamily C, polypeptide 189913Inparanoid, OMA
Pig403215CYP2C49cytochrome P450 2C499823Inparanoid, OMA

Associated Approved Drugs

    Associated Active Ligands

      Bibliography

      1.Ibeanu, G C GC and 9 more authors. 1998-04 An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians. [PMID:10022751]
      2.Foster, D J DJ, Somogyi, A A AA and Bochner, F F. 1999-04 Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4. [PMID:10233205]
      3.Ibeanu, G C GC and 9 more authors. 1999-08 A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. [PMID:10411572]
      4.Roddam, P L PL and 6 more authors. 2000-10 Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia. [PMID:11037802]
      5.Hartley, J L JL, Temple, G F GF and Brasch, M A MA. 2000-11 DNA cloning using in vitro site-specific recombination. [PMID:11076863]
      6.Griese, E U EU and 8 more authors. 2001-02 Allele and genotype frequencies of polymorphic cytochromes P4502D6, 2C19 and 2E1 in aborigines from western Australia. [PMID:11207032]
      7.Furuta, T T and 8 more authors. 2001-03 Effect of genotypic differences in CYP2C19 on cure rates for Helicobacter pylori infection by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin. [PMID:11240980]
      8.Povey, A A and 5 more authors. 2001-03 Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solvents. [PMID:11263781]
      9.Dandara, C C and 7 more authors. 2001-04 Genetic polymorphism of CYP2D6 and CYP2C19 in east- and southern African populations including psychiatric patients. [PMID:11372584]
      10.Sakai, T T and 11 more authors. 2001-06 CYP2C19 genotype and pharmacokinetics of three proton pump inhibitors in healthy subjects. [PMID:11474773]