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| Description | Cytochrome P450 2A6 |
|---|
Gene and Protein Information
| Gene ID | 1548 |
|---|---|
| Uniprot Accession IDs | P11509 A7YAE5 B2R7F6 P00190 P10890 Q16803 Q4VAT9 Q4VAU0 Q4VAU1 Q9H1Z7 Q9UCU0 Q9UK48 |
| Ensembl ID | ENSP00000301141 |
| Symbol | CYP2A3 CPA6 CYP2A CYP2A3 P450PB CYPIIA6 P450C2A |
| Family | Belongs to the cytochrome P450 family. |
| Sequence | MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Macaque | CYP2A23 | cytochrome P450, family 2, subfamily A, polypeptide 23 precursor [Source:RefSeq peptide;Acc:NP_001035306] | 9544 | OMA, EggNOG | ||
| Mouse | 13086 | Cyp2a4 | cytochrome P450, family 2, subfamily a, polypeptide 4 | 10090 | MGI:88596 | OMA, EggNOG |
| Horse | 100146413 | LOC100146413 | cytochrome P450 2A13 | 9796 | Inparanoid, EggNOG |
Associated Antibodies
Associated Approved Drugs
Associated Active Ligands
Associated Diseases
Bibliography
| 1.Oscarson, M M and 8 more authors. 1999-10-29 Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism. [PMID:10544257] |
| 2.Pelkonen, O O, Rautio, A A, Raunio, H H and Pasanen, M M. 2000-04-03 CYP2A6: a human coumarin 7-hydroxylase. [PMID:10781881] |
| 3.Zabetian, C P CP, Gelernter, J J and Cubells, J F JF. 2000-10-09 Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence. [PMID:11054771] |
| 4.Loriot, M A MA and 9 more authors. 2001-02 Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population. [PMID:11207029] |
| 5.Ariyoshi, N N, Sawamura , Y Y and Kamataki, T T. 2001-03-02 A novel single nucleotide polymorphism altering stability and activity of CYP2a6. [PMID:11237731] |
| 6.Tan, W W and 5 more authors. 2001-03-20 Frequency of CYP2A6 gene deletion and its relation to risk of lung and esophageal cancer in the Chinese population. [PMID:11241319] |
| 7.Tyndale, R F RF and Sellers, E M EM. 2001-04 Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk. [PMID:11259349] |
| 8.Kitagawa, K K, Kunugita, N N, Kitagawa, M M and Kawamoto, T T. 2001-05-25 CYP2A6*6, a novel polymorphism in cytochrome p450 2A6, has a single amino acid substitution (R128Q) that inactivates enzymatic activity. [PMID:11278503] |
| 9.Kwon, J T JT and 9 more authors. 2001-06 Nicotine metabolism and CYP2A6 allele frequencies in Koreans. [PMID:11434509] |
| 10.Paschke, T T and 6 more authors. 2001-11-30 Comparison of cytochrome P450 2A6 polymorphism frequencies in Caucasians and African-Americans using a new one-step PCR-RFLP genotyping method. [PMID:11684323] |