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CD80

DescriptionT-lymphocyte activation antigen CD80

Gene and Protein Information

Gene ID941
Uniprot Accession IDs Q5DTA9 Q5DTB0
Ensembl ID ENSP00000264246
Symbol CD28LG CD28LG1 LAB7 B7 BB1 B7-1 B7.1 LAB7 CD28LG CD28LG1
Sequence
MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp470892CD80CD80 molecule9598VGNC:1767OMA, EggNOG
Mouse12519Cd80CD80 antigen10090MGI:101775Inparanoid, OMA, EggNOG
Rat25408Cd80Cd80 molecule10116RGD:2314Inparanoid, OMA, EggNOG
Dog403765CD80CD80 molecule9615VGNC:38975Inparanoid, OMA, EggNOG
HorseCD80CD80 molecule [Source:HGNC Symbol;Acc:HGNC:1700]9796OMA, EggNOG
Cow407131CD80CD80 molecule9913VGNC:27048Inparanoid, OMA, EggNOG
Pig397161CD80CD80 molecule9823Inparanoid, EggNOG
Opossum103097997CD80CD80 molecule13616Inparanoid, OMA, EggNOG
Chicken768950CD80CD80 molecule9031CGNC:11535Inparanoid, OMA, EggNOG
Anole lizard103278386vtcn1V-set domain containing T-cell activation inhibitor 128377OMA, EggNOG

Associated Recombinant Proteins

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NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
Galiximab (anti-CD80)Cynomolgus monkey,Human
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
In stock
Expand
CD80 Armenian Hamster mAbMouse
  • Flow Cytometry
In stock
Expand
Recombinant CD80 AntibodyHuman
  • WB
Out of Stock
Expand

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      cutaneous lupus erythematosus1094Expression AtlasMONDO:0005282
      interstitial cystitis2307Expression AtlasMONDO:0018301
      invasive ductal carcinoma2965Expression AtlasMONDO:0004953
      lung carcinoma2913Expression AtlasMONDO:0005138
      osteosarcoma7970Expression AtlasMONDO:0009807
      ovarian cancer8576Expression AtlasMONDO:0008170
      psoriasis6696Expression AtlasMONDO:0005083
      tuberculosis2482Expression AtlasMONDO:0018076
      Celiac Disease17CTDMONDO:0005130
      Liver Cirrhosis, Biliary57CTDMONDO:0005388

      Bibliography

      1.Ikemizu, S S and 7 more authors. 2000-01 Structure and dimerization of a soluble form of B7-1. [PMID:10661405]
      2.Knolle, P A PA and Gerken, G G. 2000-04 Local control of the immune response in the liver. [PMID:10807504]
      3.Yang, Y H YH, Chen, M C MC, Tsai, M J MJ, Lin, Y T YT and Chiang, B L BL. 2000-09 Costimulatory molecules expression and cytokine profiles of cord blood mononuclear cells in newborns with low and high risk of developing atopic diseases. [PMID:11045378]
      4.Hakonarson, H H, Kim, C C, Whelan, R R, Campbell, D D and Grunstein, M M MM. 2001-01-01 Bi-directional activation between human airway smooth muscle cells and T lymphocytes: role in induction of altered airway responsiveness. [PMID:11123305]
      5.Omari, K I KI and Dorovini-Zis, K K. 2001-02-01 Expression and function of the costimulatory molecules B7-1 (CD80) and B7-2 (CD86) in an in vitro model of the human blood--brain barrier. [PMID:11137584]
      6.Varis, I I and 5 more authors. 2001-02 Expression of HLA-DR, CAM and co-stimulatory molecules on cord blood monocytes. [PMID:11168518]
      7.Henz, B M BM, Maurer, M M, Lippert, U U, Worm, M M and Babina, M M. 2001-02 Mast cells as initiators of immunity and host defense. [PMID:11168574]
      8.Yamanaka, T T and 5 more authors. 2001-01 M cell pockets of human Peyer's patches are specialized extensions of germinal centers. [PMID:11169444]
      9.Matsushita, M M, Tsuchiya, N N, Oka, T T, Yamane, A A and Tokunaga, K K. 2000-10 New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. [PMID:11196673]
      10.Ferlazzo, G G, Semino, C C and Melioli, G G. 2001-02-01 HLA class I molecule expression is up-regulated during maturation of dendritic cells, protecting them from natural killer cell-mediated lysis. [PMID:11222911]