PMS2

Description	Mismatch repair endonuclease PMS2

Gene and Protein Information

Gene ID	5395
Uniprot Accession IDs	B2R610 Q52LH6 Q5FBW9 Q5FBX1 Q5FBX2 Q75MR2
Ensembl ID	ENSP00000265849
Symbol	PMSL2 MLH4 PMSL2 HNPCC4 PMS2CL
Family	Belongs to the DNA mismatch repair MutL/HexB family.
Sequence	MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKEYAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPAKVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRLREAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHGPSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAPKTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDMSASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAAEDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGPQDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHPWNCPHGRPTMRHIANLGVISQN Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	463257	LOC463257	mismatch repair endonuclease PMS2	9598		OMA, EggNOG
Mouse	18861	Pms2	PMS1 homolog2, mismatch repair system component	10090	MGI:104288	Inparanoid, OMA, EggNOG
Rat	288479	Pms2	PMS1 homolog 2, mismatch repair system component	10116	RGD:1305483	Inparanoid, OMA
Dog	479751	PMS2	PMS1 homolog 2, mismatch repair system component	9615	VGNC:54058	Inparanoid, OMA, EggNOG
Horse	100062380	PMS2	PMS1 homolog 2, mismatch repair system component	9796	VGNC:51217	Inparanoid, OMA, EggNOG
Cow		PMS2	PMS1 homolog 2, mismatch repair system component [Source:HGNC Symbol;Acc:HGNC:9122]	9913		OMA, EggNOG
Pig	100514342	PMS2	PMS1 homolog 2, mismatch repair system component	9823		Inparanoid, OMA, EggNOG
Opossum	100027220	PMS2	PMS1 homolog 2, mismatch repair system component	13616		Inparanoid, OMA, EggNOG
Platypus	100081757	PMS2	PMS1 homolog 2, mismatch repair system component	9258		Inparanoid, OMA, EggNOG
Anole lizard	100564282	pms2	PMS1 homolog 2, mismatch repair system component	28377		Inparanoid, OMA, EggNOG
Xenopus		pms2	PMS1 homolog 2, mismatch repair system component [Source:Xenbase;Acc:XB-GENE-998793]	8364		OMA, EggNOG
Zebrafish	565276	pms2	PMS1 homolog 2, mismatch repair system component	7955	ZDB-GENE-030131-686	Inparanoid, OMA, EggNOG
C. elegans	179587	pms-2	PMS (Post Meiotic Segregation) family	6239		Inparanoid, OMA, EggNOG
Fruitfly	36705	Pms2	CG8169 gene product from transcript CG8169-RA	7227	FBgn0011660	Inparanoid, EggNOG
S.cerevisiae	855642	PMS1	ATP-binding mismatch repair protein	4932	S000005026	Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein / nucleic acid binding / DNA binding protein / Mismatch repair endonuclease PMS2

DTO Classes
protein / Nucleic acid binding / DNA binding protein / Mismatch repair endonuclease PMS2

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Associated Antibodies

Name	Specifications	Species reactivity	species	Application	View Details

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Disease Type	Mondoid

Pathway

Data Source	Name	Explore more targets	Explore in Source

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