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| Description | Runt-related transcription factor 2 |
|---|
Gene and Protein Information
| Gene ID | 860 |
|---|---|
| Uniprot Accession IDs | Q13950 O14614 O14615 O95181 |
| Ensembl ID | ENSP00000360493 |
| Symbol | AML3 CBFA1 OSF2 PEBP2A CCD AML3 CCD1 CLCD OSF2 CBFA1 OSF-2 PEA2aA PEBP2aA CBF-alpha-1 |
| Sequence | MASNSLFSTVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSTLSKKSQAGASELGPFSDPRQFPSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQSQSGPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTTSNGSTLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 472017 | RUNX2 | runt related transcription factor 2 | 9598 | VGNC:7908 | OMA, EggNOG |
| Macaque | 703331 | LOC703331 | runt-related transcription factor 2 | 9544 | OMA, EggNOG | |
| Mouse | 12393 | Runx2 | runt related transcription factor 2 | 10090 | MGI:99829 | Inparanoid, OMA, EggNOG |
| Rat | 367218 | Runx2 | runt-related transcription factor 2 | 10116 | RGD:2282 | OMA, EggNOG |
| Horse | RUNX2 | runt related transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10472] | 9796 | OMA, EggNOG | ||
| Cow | 536911 | RUNX2 | runt related transcription factor 2 | 9913 | VGNC:34220 | Inparanoid, OMA, EggNOG |
| Opossum | 100619969 | RUNX2 | runt related transcription factor 2 | 13616 | Inparanoid, OMA, EggNOG | |
| Platypus | RUNX2 | runt related transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10472] | 9258 | OMA, EggNOG | ||
| Anole lizard | 100555776 | runx2 | runt related transcription factor 2 | 28377 | Inparanoid, OMA, EggNOG | |
| Xenopus | 100189546 | runx2 | runt related transcription factor 2 | 8364 | XB-GENE-482021 | Inparanoid, OMA, EggNOG |
| Zebrafish | 405784 | runx2a | runt-related transcription factor 2a | 7955 | ZDB-GENE-040629-3 | Inparanoid, OMA |
Protein Classes
PANTHER Classes
protein / Runt transcription factor / Runt-related transcription factor 2
protein / transcription factor / Runt-related transcription factor 2
protein / nucleic acid binding / Runt-related transcription factor 2
protein / Runt transcription factor / Runt-related transcription factor 2
protein / transcription factor / Runt-related transcription factor 2
protein / nucleic acid binding / Runt-related transcription factor 2
DTO Classes
protein / Transcription factor / Immunoglobulin fold transcription factor / Runt transcription factor / Runt-related transcription factor 2
protein / Transcription factor / Immunoglobulin fold transcription factor / Runt transcription factor / Runt-related transcription factor 2
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Availability | View Details |
|---|
Associated Antibodies
| Name | Specifications | Species reactivity | Application | Availability | View Details |
|---|---|---|---|---|---|
| Recombinant RUNX2 Antibody | Human,Mouse,Rat |
Out of Stock
| Expand⌵ | ||
| Recombinant RUNX1/2/3 Antibody | Human,Mouse,Rat |
Out of Stock
| Expand⌵ |
Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Direct Associated Targets | Disease Type | Mondoid |
|---|
Bibliography
| 1.Yagi, R R, Chen, L F LF, Shigesada, K K, Murakami, Y Y and Ito, Y Y. 1999-05-04 A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. [PMID:10228168] |
| 2.Jiménez, M J MJ and 5 more authors. 1999-06 Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. [PMID:10330183] |
| 3.Quack, I I and 12 more authors. 1999-11 Mutation analysis of core binding factor A1 in patients with cleidocranial dysplasia. [PMID:10521292] |
| 4.Ning, Y M YM and Robins, D M DM. 1999-10-22 AML3/CBFalpha1 is required for androgen-specific activation of the enhancer of the mouse sex-limited protein (Slp) gene. [PMID:10521447] |
| 5.Hanai, J J and 13 more authors. 1999-10-29 Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter. [PMID:10531362] |
| 6.Zhou, G G and 11 more authors. 1999-11 CBFA1 mutation analysis and functional correlation with phenotypic variability in cleidocranial dysplasia. [PMID:10545612] |
| 7.Zhang, Y W YW and 13 more authors. 2000-02-22 PEBP2alphaA/CBFA1 mutations in Japanese cleidocranial dysplasia patients. [PMID:10689183] |
| 8.Haÿ, E E and 5 more authors. 2000-04 N- and E-cadherin mediate early human calvaria osteoblast differentiation promoted by bone morphogenetic protein-2. [PMID:10699973] |
| 9.Drissi, H H and 12 more authors. 2000-09 Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene. [PMID:10911365] |
| 10.Zhang, Y W YW and 9 more authors. 2000-09-12 A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. [PMID:10962029] |