Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

SLC29A2

DescriptionEquilibrative nucleoside transporter 2

Gene and Protein Information

Gene ID3177
Uniprot Accession IDs Q14542 B3KPY7 O43530 Q52M84 Q96R00 Q9UPE0
Ensembl ID ENSP00000350024
Symbol DER12 ENT2 HNP36 ENT2 DER12 HNP36
FamilyBelongs to the SLC29A/ENT transporter (TC 2.A.57) family.
Sequence
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTGPEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVDMSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAELLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLVFTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRLLPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL
Show more
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp451345SLC29A2solute carrier family 29 member 29598VGNC:7749OMA, EggNOG
Macaque720038SLC29A2solute carrier family 29 member 29544OMA, EggNOG
Mouse13340Slc29a2solute carrier family 29 (nucleoside transporters), member 210090MGI:1345278Inparanoid, OMA, EggNOG
Rat108348052LOC108348052equilibrative nucleoside transporter 210116RGD:11407640OMA, EggNOG
Dog611913SLC29A2solute carrier family 29 member 29615VGNC:46334Inparanoid, OMA, EggNOG
Horse100052412SLC29A2solute carrier family 29 member 29796VGNC:23137Inparanoid, OMA, EggNOG
Cow531564SLC29A2solute carrier family 29 member 29913VGNC:34794Inparanoid, OMA, EggNOG
Pig100518596SLC29A2solute carrier family 29 member 29823Inparanoid, OMA, EggNOG
OpossumSLC29A2solute carrier family 29 member 2 [Source:HGNC Symbol;Acc:HGNC:11004]13616Inparanoid, OMA, EggNOG
Xenopus548864slc29a2solute carrier family 29 (equilibrative nucleoside transporter), member 28364XB-GENE-5904465Inparanoid, OMA, EggNOG
Zebrafish503537slc29a2solute carrier family 29 (equilibrative nucleoside transporter), member 27955ZDB-GENE-050220-15OMA, EggNOG
S.cerevisiae851211FUN26nucleoside transmembrane transporter FUN264932S000000020Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    transporter    /    Equilibrative nucleoside transporter 2
DTO Classes
protein    /    Transporter    /    SLC superfamily of solute carriers    /    SLC28 and SLC29 families of nucleoside transporters    /    SLC29 family    /    Equilibrative nucleoside transporter 2

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
Recombinant ENT2 AntibodyHuman,Mouse
  • IF/ICC
  • IHC
  • WB
In stock
Expand

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      group 3 medulloblastoma7142Expression AtlasMONDO:0007959
      malignant mesothelioma3244Expression AtlasMONDO:0006292
      osteosarcoma7970Expression AtlasMONDO:0009807
      ovarian cancer8576Expression AtlasMONDO:0008170
      Prostate carcinoma0JensenLab Experiment TIGA
      Attention deficit hyperactivity disorder0JensenLab Experiment TIGA
      Gout0JensenLab Experiment TIGA
      Breast carcinoma0JensenLab Experiment TIGA
      Ovarian carcinoma0JensenLab Experiment TIGA

      Bibliography

      1.Yao, Sylvia Y M SY and 6 more authors. 2002-07-12 Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation. [PMID:12006583]
      2.Molina-Arcas, Míriam M and 6 more authors. 2003-03-15 Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. [PMID:12411296]
      3.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      4.Mangravite, Lara M LM, Xiao, Guangqing G and Giacomini, Kathleen M KM. 2003-05 Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. [PMID:12527552]
      5.Ward, Jeffrey L JL, Leung, George P H GP, Toan, Shuy-Vang SV and Tse, Chung-Ming CM. 2003-03-01 Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2. [PMID:12590919]
      6.Szkotak, A J AJ and 6 more authors. 2003-04-01 Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells. [PMID:12820662]
      7.Baldwin, Stephen A SA and 5 more authors. 2004-02 The equilibrative nucleoside transporter family, SLC29. [PMID:12838422]
      8.Mangravite, Lara M LM, Badagnani, Ilaria I and Giacomini, Kathleen M KM. 2003-10-31 Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney. [PMID:14612157]
      9.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039]
      10.Farré, Xavier X and 8 more authors. 2004-12-20 Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. [PMID:15386342]