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CSF2

DescriptionGranulocyte-macrophage colony-stimulating factor

Gene and Protein Information

Gene ID1437
Uniprot Accession IDs Q14CE8 Q2VPI8 Q8NFI6 GM-CSF
Ensembl ID ENSP00000296871
Symbol GMCSF CSF GMCSF
FamilyBelongs to the GM-CSF family.
Sequence
MWLQSLLLLGTVACSISAPARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp471627CSF2colony stimulating factor 29598VGNC:6847OMA, EggNOG
Macaque574371CSF2colony stimulating factor 29544OMA, EggNOG
Mouse12981Csf2colony stimulating factor 2 (granulocyte-macrophage)10090MGI:1339752Inparanoid, OMA, EggNOG
Rat116630Csf2colony stimulating factor 210116RGD:621065Inparanoid, OMA, EggNOG
Dog403923CSF2colony stimulating factor 29615VGNC:39654Inparanoid, OMA, EggNOG
Horse100033981CSF2colony stimulating factor 29796VGNC:16897OMA, EggNOG
Cow281095CSF2colony stimulating factor 29913VGNC:27755Inparanoid, OMA, EggNOG
Pig397208CSF2colony stimulating factor 29823Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    signaling molecule    /    cytokine    /    Granulocyte-macrophage colony-stimulating factor
DTO Classes
protein    /    Signaling    /    Cytokine    /    Granulocyte-macrophage colony-stimulating factor

Associated Recombinant Proteins

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      Bibliography

      1.Stomski, F C FC and 9 more authors. 1999-09-15 Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF. [PMID:10477722]
      2.Niu, L L, Golde, D W DW, Vera, J C JC and Heaney, M L ML. 1999-12-01 Kinetic resolution of two mechanisms for high-affinity granulocyte-macrophage colony-stimulating factor binding to its receptor. [PMID:10572088]
      3.Scheuerer, B B and 7 more authors. 2000-02-15 The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages. [PMID:10666185]
      4.Modrowski, D D, Baslé, M M, Lomri, A A and Marie, P J PJ. 2000-03-31 Syndecan-2 is involved in the mitogenic activity and signaling of granulocyte-macrophage colony-stimulating factor in osteoblasts. [PMID:10734053]
      5.Kajita, M M and 6 more authors. 2001 Novel single nucleotide polymorphisms of the human colony-stimulating factor 2 (CSF2) gene identified by sequencing the entire gene. [PMID:11289721]
      6.Seldon, P M PM and Giembycz, M A MA. 2001-09 Suppression of granulocyte/macrophage colony-stimulating factor release from human monocytes by cyclic AMP-elevating drugs: role of interleukin-10. [PMID:11522597]
      7.Allam, M M and Renzi, P M PM. 2001-10 Inhibition of GM-CSF/IL-3/IL-5 signaling by antisense oligodeoxynucleotides targeting the common beta chain of their receptors. [PMID:11763346]
      8.Feugier, Pierre P and 6 more authors. 2002-02 Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand. [PMID:11847009]
      9.Pituch-Noworolska, A A, Hajto, B B, Balwierz, W W and Klus, K K. 2001 Induction of apoptosis and bcl-2 expression in acute lymphoblastic leukaemia and non-Hodgkin's lymphoma in children. [PMID:11855781]
      10.Sabatini, Federica F, Silvestri, Michela M, Scarso, Lucia L, Brazzola, Giancarlo G and Rossi, Giovanni A GA. 2002-02 The antiinflammatory activity of budesonide on human airway epithelial cells is lasting after removal of the drug from cultures. [PMID:11883735]