ROCK2

Description	Rho-associated protein kinase 2

Gene and Protein Information

Gene ID	9475
Uniprot Accession IDs	Q53QZ0 Q53SJ7 Q9UQN5
Ensembl ID	ENSP00000317985
Symbol	KIAA0619 ROCK-II
Family	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Sequence	MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	470307	ROCK2	Rho associated coiled-coil containing protein kinase 2	9598	VGNC:6655	OMA, EggNOG
Macaque	708444	ROCK2	Rho associated coiled-coil containing protein kinase 2	9544		Inparanoid, OMA, EggNOG
Mouse	19878	Rock2	Rho-associated coiled-coil containing protein kinase 2	10090	MGI:107926	Inparanoid, OMA, EggNOG
Rat	25537	Rock2	Rho-associated coiled-coil containing protein kinase 2	10116	RGD:3590	Inparanoid, OMA, EggNOG
Dog	482970	ROCK2	Rho associated coiled-coil containing protein kinase 2	9615	VGNC:49640	Inparanoid, OMA, EggNOG
Horse	100072339	ROCK2	Rho associated coiled-coil containing protein kinase 2	9796	VGNC:22497	Inparanoid, OMA, EggNOG
Cow	282041	ROCK2	Rho associated coiled-coil containing protein kinase 2	9913	VGNC:34082	Inparanoid, OMA, EggNOG
Pig	397445	ROCK2	Rho associated coiled-coil containing protein kinase 2	9823		Inparanoid, OMA, EggNOG
Opossum	100032706	ROCK2	Rho associated coiled-coil containing protein kinase 2	13616		Inparanoid, EggNOG
Anole lizard	100562729	rock2	Rho associated coiled-coil containing protein kinase 2	28377		Inparanoid, OMA, EggNOG
Xenopus	100493965	rock2	Rho-associated, coiled-coil containing protein kinase 2	8364	XB-GENE-959451	Inparanoid, OMA
Zebrafish	317747	rock2a	rho-associated, coiled-coil containing protein kinase 2a	7955	ZDB-GENE-030115-3	Inparanoid, OMA, EggNOG
C. elegans	172088	let-502	Rho-associated protein kinase let-502	6239		Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    non-receptor serine/threonine protein kinase    /    Rho-associated protein kinase 2
protein    /    protein kinase    /    Rho-associated protein kinase 2
protein    /    transferase    /    Rho-associated protein kinase 2
protein    /    kinase    /    Rho-associated protein kinase 2

DTO Classes
protein / Kinase / Protein kinase / AGC group / DMPK family / ROCK subfamily / Rho-associated protein kinase 2

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Associated Antibodies

Name	Specifications	Species reactivity	species	Application	View Details

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Disease Type	Mondoid

Pathway

Data Source	Name	Explore more targets	Explore in Source

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