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SLC12A1

DescriptionSolute carrier family 12 member 1

Gene and Protein Information

Gene ID6557
Uniprot Accession IDs A8JYA2 E9PDW4
Ensembl ID ENSP00000379822
Symbol NKCC2 BSC1 NKCC2
FamilyBelongs to the SLC12A transporter family.
Sequence
MSLNNSSNVFLDSVPSNTNRFQVSVINENHESSAAADDNTDPPHYEETSFGDEAQKRLRISFRPGNQECYDNFLQSGETAKTDASFHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVANGDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp453410SLC12A1solute carrier family 12 member 19598VGNC:7779Inparanoid, OMA, EggNOG
Macaque714289SLC12A1solute carrier family 12 member 19544Inparanoid, OMA, EggNOG
Mouse20495Slc12a1solute carrier family 12, member 110090MGI:103150Inparanoid, OMA, EggNOG
Rat25065Slc12a1solute carrier family 12 member 110116RGD:3685Inparanoid, OMA, EggNOG
Dog478292SLC12A1solute carrier family 12 member 19615VGNC:46218Inparanoid, OMA, EggNOG
Horse100055787SLC12A1solute carrier family 12 member 19796VGNC:23019Inparanoid, OMA, EggNOG
Cow407161SLC12A1solute carrier family 12 member 19913VGNC:34664OMA, EggNOG
Pig100154291SLC12A1solute carrier family 12 member 19823OMA, EggNOG
Opossum100025723SLC12A1solute carrier family 12 member 113616Inparanoid, EggNOG
Chicken415433SLC12A1solute carrier family 12 member 19031CGNC:3673Inparanoid, OMA
Zebrafish100329975slc12a1solute carrier family 12 (sodium/potassium/chloride transporter), member 17955ZDB-GENE-080130-3Inparanoid, OMA

Protein Classes

DTO Classes
protein    /    Transporter    /    SLC superfamily of solute carriers    /    SLC12 family of cation-coupled chloride transporters    /    Solute carrier family 12 member 1

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      Bibliography

      1.Glorioso, N N and 8 more authors. 2001-08 Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension. [PMID:11509477]
      2.Song, Y Y and 6 more authors. 2001-09 Non-association of the thiazide-sensitive Na,Cl-cotransporter gene with polygenic hypertension in both rats and humans. [PMID:11564973]
      3.Iwamoto, Lynn M LM, Nakamura, Kenneth T KT and Wada, Randal K RK. 2003-04 Immunolocalization of a Na-K-2Cl cotransporter in human tracheobronchial smooth muscle. [PMID:12471046]
      4.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      5.Starremans, Patrick G J F PG, Kersten, Ferry F J FF, Knoers, Nine V A M NV, van den Heuvel, Lambertus P W J LP and Bindels, René J M RJ. 2003-06 Mutations in the human Na-K-2Cl cotransporter (NKCC2) identified in Bartter syndrome type I consistently result in nonfunctional transporters. [PMID:12761241]
      6.Lindinger, Michael I MI and Grudzien, Simon P SP. 2003-12-15 Exercise-induced changes in plasma composition increase erythrocyte Na+,K+-ATPase, but not Na+-K+-2Cl- cotransporter, activity to stimulate net and unidirectional K+ transport in humans. [PMID:14528028]
      7.Aviv, Abraham A, Hollenberg, Norman K NK and Weder, Alan A. 2004-04 Urinary potassium excretion and sodium sensitivity in blacks. [PMID:14967834]
      8.Iwai, Naoharu N and 6 more authors. 2004-06 Genetic analysis of 22 candidate genes for hypertension in the Japanese population. [PMID:15167446]
      9.Pisitkun, Trairak T, Shen, Rong-Fong RF and Knepper, Mark A MA. 2004-09-07 Identification and proteomic profiling of exosomes in human urine. [PMID:15326289]
      10.Kimura, Kouichi K and 31 more authors. 2006-01 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. [PMID:16344560]