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ROCK1

DescriptionRho-associated protein kinase 1

Gene and Protein Information

Gene ID6093
Uniprot Accession IDs B0YJ91 Q2KHM4 Q59GZ4
Ensembl ID ENSP00000382697
Symbol ROCK-I P160ROCK
FamilyBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Sequence
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp455326ROCK1Rho associated coiled-coil containing protein kinase 19598VGNC:7330OMA, EggNOG
Macaque698223ROCK1Rho associated coiled-coil containing protein kinase 19544Inparanoid, OMA, EggNOG
Mouse19877Rock1Rho-associated coiled-coil containing protein kinase 110090MGI:107927Inparanoid, OMA, EggNOG
Rat81762Rock1Rho-associated coiled-coil containing protein kinase 110116RGD:620424Inparanoid, OMA, EggNOG
Dog480181ROCK1Rho associated coiled-coil containing protein kinase 19615VGNC:45688Inparanoid, OMA, EggNOG
Horse100034056ROCK1Rho associated coiled-coil containing protein kinase 19796VGNC:22496Inparanoid, OMA, EggNOG
Cow785911ROCK1Rho associated coiled-coil containing protein kinase 19913OMA, EggNOG
Pig397447ROCK1Rho associated coiled-coil containing protein kinase 19823Inparanoid, OMA, EggNOG
Opossum100618269ROCK1Rho associated coiled-coil containing protein kinase 113616Inparanoid, OMA
Chicken373970ROCK1Rho-associated, coiled-coil containing protein kinase 19031CGNC:11078Inparanoid, OMA
Anole lizard100558337rock1Rho associated coiled-coil containing protein kinase 128377Inparanoid, OMA
Zebrafish100329779rock1Rho-associated, coiled-coil containing protein kinase 17955ZDB-GENE-100712-2Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    non-receptor serine/threonine protein kinase    /    Rho-associated protein kinase 1
protein    /    protein kinase    /    Rho-associated protein kinase 1
protein    /    transferase    /    Rho-associated protein kinase 1
protein    /    kinase    /    Rho-associated protein kinase 1
DTO Classes
protein    /    Kinase    /    Protein kinase    /    AGC group    /    DMPK family    /    ROCK subfamily    /    Rho-associated protein kinase 1

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      adult high grade glioma4998Expression AtlasMONDO:0100342
      osteosarcoma7970Expression AtlasMONDO:0009807
      Prenatal Injuries0CTD
      Prenatal Injuries0DisGeNET
      Cerebral ischemia0DrugCentral Indication
      Spasm of cerebral arteries0DrugCentral Indication
      Glaucoma0DrugCentral Indication
      Ocular hypertension0DrugCentral Indication
      Chronic graft-versus-host disease (chronic GVHD)0DrugCentral Indication

      Bibliography

      1.Fukata, Y Y and 7 more authors. 1999-04-19 Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. [PMID:10209029]
      2.Maekawa, M M and 9 more authors. 1999-08-06 Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. [PMID:10436159]
      3.Scanlan, M J MJ and 11 more authors. 1999-11-12 Antigens recognized by autologous antibody in patients with renal-cell carcinoma. [PMID:10508479]
      4.Edwards, D C DC, Sanders, L C LC, Bokoch, G M GM and Gill, G N GN. 1999-09 Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. [PMID:10559936]
      5.Inada, H H and 5 more authors. 1999-12-03 Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments. [PMID:10574968]
      6.Kawano, Y Y and 8 more authors. 1999-11-29 Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. [PMID:10579722]
      7.Feng, J J and 6 more authors. 1999-12-24 Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. [PMID:10601309]
      8.Ohashi, K K and 5 more authors. 2000-02-04 Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. [PMID:10652353]
      9.Arimura, N N and 8 more authors. 2000-08-04 Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse. [PMID:10818093]
      10.Tran Quang, C C, Gautreau, A A, Arpin, M M and Treisman, R R. 2000-09-01 Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes. [PMID:10970850]