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| Description | Signal transducer and activator of transcription 1-alpha/beta |
|---|
Gene and Protein Information
| Gene ID | 6772 |
|---|---|
| Uniprot Accession IDs | P42224 A8K989 B2RCA0 D2KFR8 D3DPI7 Q53S88 Q53XW4 Q68D00 Q9UDL5 |
| Ensembl ID | ENSP00000354394 |
| Symbol | CANDF7 IMD31A IMD31B IMD31C ISGF-3 STAT91 |
| Family | Belongs to the transcription factor STAT family. |
| Sequence | MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 459834 | STAT1 | signal transducer and activator of transcription 1 | 9598 | VGNC:2869 | OMA, EggNOG |
| Macaque | 693650 | STAT1 | signal transducer and activator of transcription 1 | 9544 | Inparanoid, OMA, EggNOG | |
| Mouse | 20846 | Stat1 | signal transducer and activator of transcription 1 | 10090 | MGI:103063 | Inparanoid, OMA, EggNOG |
| Horse | 100069633 | STAT1 | signal transducer and activator of transcription 1 | 9796 | VGNC:23663 | Inparanoid, OMA, EggNOG |
| Cow | 510814 | STAT1 | signal transducer and activator of transcription 1, 91kDa | 9913 | Inparanoid, EggNOG | |
| Pig | 396655 | STAT1 | signal transducer and activator of transcription 1 | 9823 | Inparanoid, OMA, EggNOG | |
| Opossum | 100028917 | STAT1 | signal transducer and activator of transcription 1 | 13616 | Inparanoid, OMA, EggNOG | |
| Xenopus | 780397 | stat1 | signal transducer and activator of transcription 1 | 8364 | XB-GENE-482166 | Inparanoid, OMA |
| Zebrafish | 30768 | stat1a | signal transducer and activator of transcription 1a | 7955 | ZDB-GENE-980526-499 | Inparanoid, OMA |
Protein Classes
PANTHER Classes
protein / transcription factor / Signal transducer and activator of transcription 1-alpha/beta
protein / nucleic acid binding / Signal transducer and activator of transcription 1-alpha/beta
protein / transcription factor / Signal transducer and activator of transcription 1-alpha/beta
protein / nucleic acid binding / Signal transducer and activator of transcription 1-alpha/beta
DTO Classes
protein / Nucleic acid binding / Signal transducer and activator of transcription 1-alpha/beta
protein / Nucleic acid binding / Signal transducer and activator of transcription 1-alpha/beta
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Availability | View Details |
|---|
Associated Antibodies
| Name | Specifications | Species reactivity | Application | Availability | View Details |
|---|
Associated Approved Drugs
Associated Active Ligands
Associated Diseases
Bibliography
| 1.Ulloa, L L, Doody, J J and Massagué, J J. 1999-02-25 Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. [PMID:10067896] |
| 2.Brizzi, M F MF, Dentelli, P P, Rosso, A A, Yarden, Y Y and Pegoraro, L L. 1999-06-11 STAT protein recruitment and activation in c-Kit deletion mutants. [PMID:10358045] |
| 3.Dumler, I I and 7 more authors. 1999-08-20 Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. [PMID:10446176] |
| 4.Zhang, X X, Wrzeszczynska, M H MH, Horvath, C M CM and Darnell, J E JE. 1999-10 Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation. [PMID:10490649] |
| 5.Vila-Coro, A J AJ and 5 more authors. 1999-10 The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. [PMID:10506573] |
| 6.Delespine-Carmagnat, M M, Bouvier, G G and Bertoglio, J J. 2000-01 Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain. [PMID:10602027] |
| 7.Sasaguri, T T, Teruya, H H, Ishida, A A, Abumiya, T T and Ogata, J J. 2000-02-05 Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells. [PMID:10652206] |
| 8.Huang, Y Q YQ, Li, J J JJ and Karpatkin, S S. 2000-03-03 Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway. [PMID:10692450] |
| 9.Cebulla, C M CM, Miller, D M DM and Sedmak, D D DD. 1999 Viral inhibition of interferon signal transduction. [PMID:10702714] |
| 10.Chatterjee-Kishore, M M, van Den Akker, F F and Stark, G R GR. 2000-07-07 Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1. [PMID:10764778] |