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TYK2

Description	Non-receptor tyrosine-protein kinase TYK2

Gene and Protein Information

Gene ID	7297
Uniprot Accession IDs	Q6QB10 Q96CH0
Ensembl ID	ENSP00000431885
Symbol	JTK1 IMD35
Family	Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Sequence	MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	455703	TYK2	tyrosine kinase 2	9598	VGNC:2210	OMA, EggNOG
Macaque	574130	TYK2	tyrosine kinase 2	9544		OMA, EggNOG
Mouse	54721	Tyk2	tyrosine kinase 2	10090	MGI:1929470	Inparanoid, OMA, EggNOG
Rat	100361294	Tyk2	tyrosine kinase 2	10116	RGD:2320469	Inparanoid, OMA, EggNOG
Dog	476714	TYK2	tyrosine kinase 2	9615	VGNC:48024	Inparanoid, OMA, EggNOG
Horse		TYK2	tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440]	9796		OMA, EggNOG
Cow	512484	TYK2	tyrosine kinase 2	9913	VGNC:36548	Inparanoid, OMA, EggNOG
Pig	397363	TYK2	tyrosine kinase 2	9823		Inparanoid, OMA, EggNOG
Opossum	100012931	TYK2	tyrosine kinase 2	13616		Inparanoid, OMA, EggNOG
Anole lizard	100566727	tyk2	tyrosine kinase 2	28377		Inparanoid, OMA
Xenopus	100489432	tyk2	tyrosine kinase 2	8364	XB-GENE-993652	Inparanoid, OMA
Zebrafish	100536675	tyk2	tyrosine kinase 2	7955	ZDB-GENE-071116-4	Inparanoid, OMA

DTO Classes
protein / Kinase / Protein kinase / TK group / JAKA family / Non-receptor tyrosine-protein kinase tyk2

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Name	Specifications	Species reactivity	species	Application	View Details

Name	Disease Type	Mondoid

Data Source	Name	Explore more targets	Explore in Source