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TYK2
| Description | Non-receptor tyrosine-protein kinase TYK2 |
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Gene and Protein Information
| Gene ID | 7297 |
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| Uniprot Accession IDs | Q6QB10 Q96CH0 |
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| Ensembl ID | ENSP00000431885 |
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| Symbol | JTK1 IMD35 |
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| Family | Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. |
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| Sequence | MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC Show more |
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Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
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| Chimp | 455703 | TYK2 | tyrosine kinase 2 | 9598 | VGNC:2210 | OMA, EggNOG |
| Macaque | 574130 | TYK2 | tyrosine kinase 2 | 9544 | | OMA, EggNOG |
| Mouse | 54721 | Tyk2 | tyrosine kinase 2 | 10090 | MGI:1929470 | Inparanoid, OMA, EggNOG |
| Rat | 100361294 | Tyk2 | tyrosine kinase 2 | 10116 | RGD:2320469 | Inparanoid, OMA, EggNOG |
| Dog | 476714 | TYK2 | tyrosine kinase 2 | 9615 | VGNC:48024 | Inparanoid, OMA, EggNOG |
| Horse | | TYK2 | tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:12440] | 9796 | | OMA, EggNOG |
| Cow | 512484 | TYK2 | tyrosine kinase 2 | 9913 | VGNC:36548 | Inparanoid, OMA, EggNOG |
| Pig | 397363 | TYK2 | tyrosine kinase 2 | 9823 | | Inparanoid, OMA, EggNOG |
| Opossum | 100012931 | TYK2 | tyrosine kinase 2 | 13616 | | Inparanoid, OMA, EggNOG |
| Anole lizard | 100566727 | tyk2 | tyrosine kinase 2 | 28377 | | Inparanoid, OMA |
| Xenopus | 100489432 | tyk2 | tyrosine kinase 2 | 8364 | XB-GENE-993652 | Inparanoid, OMA |
| Zebrafish | 100536675 | tyk2 | tyrosine kinase 2 | 7955 | ZDB-GENE-071116-4 | Inparanoid, OMA |
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Activity | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | species | Application | View Details |
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Associated Approved Drugs
Associated Active Ligands
Pathway
| Data Source | Name | Explore more targets | Explore in Source |
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