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GATA4

DescriptionTranscription factor GATA-4

Gene and Protein Information

Gene ID2626
Uniprot Accession IDs P43694 B7ZKX0 B7ZKZ4 Q3MJ45 Q5IFM8
Ensembl ID ENSP00000334458
Symbol TOF ASD2 VSD1 TACHD
Sequence
MYQSLAMAANHGPPPGAYEAGGPGAFMHGAGAASSPVYVPTPRVPSSVLGLSYLQGGGAGSASGGASGGSSGGAASGAGPGTQQGSPGWSQAGADGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYSSGGGAAGAGLAGREQYGRAGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPAARHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAAPSGSESLPPASGASSNSSNATTSSSEEMRPIKTEPGLSSHYGHSSSVSQTFSVSAMSGHGPSIHPVLSALKLSPQGYASPVSQSPQTSSKQDSWNSLVLADSHGDIITA
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Macaque696775GATA4GATA binding protein 49544Inparanoid, OMA, EggNOG
Mouse14463Gata4GATA binding protein 410090MGI:95664Inparanoid, OMA, EggNOG
Rat54254Gata4GATA binding protein 410116RGD:2665Inparanoid, OMA, EggNOG
Dog486079GATA4GATA binding protein 49615Inparanoid, OMA, EggNOG
Horse100065126GATA4GATA binding protein 49796VGNC:50696Inparanoid, EggNOG
Cow327716GATA4GATA binding protein 49913VGNC:29268Inparanoid, OMA, EggNOG
Pig397555GATA4GATA binding protein 49823Inparanoid, OMA, EggNOG
Opossum100032686GATA4GATA binding protein 413616Inparanoid, EggNOG
Chicken396392GATA4GATA binding protein 49031CGNC:12483Inparanoid, OMA, EggNOG
Anole lizard100553342gata4GATA binding protein 428377Inparanoid, OMA, EggNOG
Xenopus549703gata4GATA binding protein 48364XB-GENE-487458Inparanoid, OMA, EggNOG
Zebrafish30483gata4GATA binding protein 47955ZDB-GENE-980526-476Inparanoid, OMA

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Bibliography

      1.Tremblay, J J JJ and Viger, R S RS. 1999-08 Transcription factor GATA-4 enhances Müllerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1. [PMID:10446911]
      2.Lin, L L and 5 more authors. 2000-03-01 A minimal critical region of the 8p22-23 amplicon in esophageal adenocarcinomas defined using sequence tagged site-amplification mapping and quantitative polymerase chain reaction includes the GATA-4 gene. [PMID:10728696]
      3.Morin, S S, Charron, F F, Robitaille, L L and Nemer, M M. 2000-05-02 GATA-dependent recruitment of MEF2 proteins to target promoters. [PMID:10790371]
      4.Zhu, W W and 9 more authors. 2000-11-10 Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease. [PMID:10948187]
      5.Belaguli, N S NS and 5 more authors. 2000-10 Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators. [PMID:11003651]
      6.Morin, S S, Paradis, P P, Aries, A A and Nemer, M M. 2001-02 Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor. [PMID:11158291]
      7.Crispino, J D JD and 6 more authors. 2001-04-01 Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. [PMID:11297508]
      8.Dai, Y S YS and Markham, B E BE. 2001-10-05 p300 Functions as a coactivator of transcription factor GATA-4. [PMID:11481322]
      9.Liang, Q Q and 5 more authors. 2001-11 The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes. [PMID:11585926]
      10.Crawford, Susan E SE and 7 more authors. 2002-02-01 Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. [PMID:11724781]