IDE

Description	Insulin-degrading enzyme

Gene and Protein Information

Gene ID	3416
Uniprot Accession IDs	B2R721 B7ZAU2 D3DR35 Q5T5N2
Ensembl ID	ENSP00000265986
Symbol	INSULYSIN
Family	Belongs to the peptidase M16 family.
Sequence	MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	450608	IDE	insulin degrading enzyme	9598	VGNC:7230	OMA, EggNOG
Macaque	698640	IDE	insulin degrading enzyme	9544		Inparanoid, OMA, EggNOG
Mouse	15925	Ide	insulin degrading enzyme	10090	MGI:96412	Inparanoid, OMA, EggNOG
Rat	25700	Ide	insulin degrading enzyme	10116	RGD:2861	Inparanoid, OMA, EggNOG
Dog	477768	IDE	insulin degrading enzyme	9615	VGNC:41863	Inparanoid, OMA, EggNOG
Horse	100071303	IDE	insulin degrading enzyme	9796	VGNC:18936	Inparanoid, OMA, EggNOG
Cow	523752	IDE	insulin degrading enzyme	9913	VGNC:30033	Inparanoid, OMA, EggNOG
Pig	100155309	IDE	insulin degrading enzyme	9823		Inparanoid, OMA, EggNOG
Opossum	100024067	IDE	insulin degrading enzyme	13616		Inparanoid, EggNOG
Platypus	100074945	IDE	insulin degrading enzyme	9258		Inparanoid, OMA, EggNOG
Zebrafish	561390	ide	insulin-degrading enzyme	7955	ZDB-GENE-070410-85	Inparanoid, OMA
C. elegans	182987	C28F5.4	Putative zinc protease C28F5.4	6239		Inparanoid, OMA
C. elegans	178966	F44E7.4	hypothetical protein	6239		OMA, EggNOG
Fruitfly	40248	Ide	Insulin degrading metalloproteinase	7227	FBgn0001247	Inparanoid, OMA, EggNOG
S.cerevisiae	851105	STE23	metalloendopeptidase	4932	S000004381	Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    metalloprotease    /    Insulin-degrading enzyme
protein    /    protease    /    Insulin-degrading enzyme
protein    /    hydrolase    /    Insulin-degrading enzyme

DTO Classes
protein / Enzyme / Protease / Metalloprotease / Insulin-degrading enzyme

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Associated Antibodies

Name	Specifications	Species reactivity	species	Application	View Details

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Disease Type	Mondoid

Pathway

Data Source	Name	Explore more targets	Explore in Source

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IDE