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IDE

DescriptionInsulin-degrading enzyme

Gene and Protein Information

Gene ID3416
Uniprot Accession IDs B2R721 B7ZAU2 D3DR35 Q5T5N2
Ensembl ID ENSP00000265986
Symbol INSULYSIN
FamilyBelongs to the peptidase M16 family.
Sequence
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp450608IDEinsulin degrading enzyme9598VGNC:7230OMA, EggNOG
Macaque698640IDEinsulin degrading enzyme9544Inparanoid, OMA, EggNOG
Mouse15925Ideinsulin degrading enzyme10090MGI:96412Inparanoid, OMA, EggNOG
Rat25700Ideinsulin degrading enzyme10116RGD:2861Inparanoid, OMA, EggNOG
Dog477768IDEinsulin degrading enzyme9615VGNC:41863Inparanoid, OMA, EggNOG
Horse100071303IDEinsulin degrading enzyme9796VGNC:18936Inparanoid, OMA, EggNOG
Cow523752IDEinsulin degrading enzyme9913VGNC:30033Inparanoid, OMA, EggNOG
Pig100155309IDEinsulin degrading enzyme9823Inparanoid, OMA, EggNOG
Opossum100024067IDEinsulin degrading enzyme13616Inparanoid, EggNOG
Platypus100074945IDEinsulin degrading enzyme9258Inparanoid, OMA, EggNOG
Zebrafish561390ideinsulin-degrading enzyme7955ZDB-GENE-070410-85Inparanoid, OMA
C. elegans182987C28F5.4Putative zinc protease C28F5.46239Inparanoid, OMA
C. elegans178966F44E7.4hypothetical protein6239OMA, EggNOG
Fruitfly40248IdeInsulin degrading metalloproteinase7227FBgn0001247Inparanoid, OMA, EggNOG
S.cerevisiae851105STE23metalloendopeptidase4932S000004381Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    metalloprotease    /    Insulin-degrading enzyme
protein    /    protease    /    Insulin-degrading enzyme
protein    /    hydrolase    /    Insulin-degrading enzyme
DTO Classes
protein    /    Enzyme    /    Protease    /    Metalloprotease    /    Insulin-degrading enzyme

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelActivityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityspeciesApplicationView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDisease TypeMondoid

      Pathway

      Data SourceNameExplore more targetsExplore in Source
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