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| Description | Bifunctional epoxide hydrolase 2 |
|---|
Gene and Protein Information
| Gene ID | 2053 |
|---|---|
| Uniprot Accession IDs | P34913 B2Z3B1 B3KTU8 B3KUA0 G3V134 J3KPH7 Q16764 Q9HBJ1 Q9HBJ2 |
| Ensembl ID | ENSP00000430269 |
| Symbol | CEH SEH ABHD20 |
| Family | Belongs to the AB hydrolase superfamily. Epoxide hydrolase family. |
| Sequence | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 464074 | EPHX2 | epoxide hydrolase 2 | 9598 | VGNC:11967 | OMA, EggNOG |
| Macaque | 712926 | EPHX2 | epoxide hydrolase 2 | 9544 | OMA, EggNOG | |
| Mouse | 13850 | Ephx2 | epoxide hydrolase 2, cytoplasmic | 10090 | MGI:99500 | Inparanoid, OMA, EggNOG |
| Rat | 65030 | Ephx2 | epoxide hydrolase 2 | 10116 | RGD:620732 | Inparanoid, OMA, EggNOG |
| Dog | 477373 | EPHX2 | epoxide hydrolase 2 | 9615 | VGNC:40416 | Inparanoid, OMA, EggNOG |
| Horse | 100060414 | EPHX2 | epoxide hydrolase 2 | 9796 | VGNC:17627 | Inparanoid, OMA, EggNOG |
| Pig | 414425 | EPHX2 | epoxide hydrolase 2 | 9823 | Inparanoid, OMA, EggNOG | |
| Opossum | 100030580 | EPHX2 | epoxide hydrolase 2 | 13616 | Inparanoid, EggNOG | |
| Chicken | 421999 | EPHX2 | epoxide hydrolase 2 | 9031 | CGNC:12409 | Inparanoid, OMA, EggNOG |
| Anole lizard | EPHX2 | epoxide hydrolase 2 [Source:HGNC Symbol;Acc:HGNC:3402] | 28377 | Inparanoid, OMA | ||
| Xenopus | 448759 | ephx2 | epoxide hydrolase 2, cytoplasmic | 8364 | XB-GENE-947544 | Inparanoid, OMA, EggNOG |
| Zebrafish | 494099 | ephx2 | epoxide hydrolase 2, cytoplasmic | 7955 | ZDB-GENE-041212-70 | Inparanoid, OMA, EggNOG |
Protein Classes
PANTHER Classes
protein / serine protease / Bifunctional epoxide hydrolase 2
protein / protease / Bifunctional epoxide hydrolase 2
protein / hydrolase / Bifunctional epoxide hydrolase 2
protein / serine protease / Bifunctional epoxide hydrolase 2
protein / protease / Bifunctional epoxide hydrolase 2
protein / hydrolase / Bifunctional epoxide hydrolase 2
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Availability | View Details |
|---|
Associated Antibodies
| Name | Specifications | Species reactivity | Application | Availability | View Details |
|---|
Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Direct Associated Targets | Disease Type | Mondoid |
|---|---|---|---|
| Hypercholesterolemia, Familial | 9 | Monarch | MONDO:0007750 |
| adrenocortical carcinoma | 1427 | Expression Atlas | MONDO:0006639 |
| atypical teratoid / rhabdoid tumor | 5491 | Expression Atlas | MONDO:0020560 |
| colon cancer | 1587 | Expression Atlas | MONDO:0021063 |
| cutaneous lupus erythematosus | 1094 | Expression Atlas | MONDO:0005282 |
| ependymoma | 5607 | Expression Atlas | MONDO:0021191 |
| inflammatory breast cancer | 3880 | Expression Atlas | MONDO:0007254 |
| interstitial cystitis | 2307 | Expression Atlas | MONDO:0018301 |
| intraductal papillary-mucinous carcinoma (IPMC) | 3017 | Expression Atlas | MONDO:0004285 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3325 | Expression Atlas | MONDO:0004286 |
Bibliography
| 1.Sandberg, M M, Hassett, C C, Adman, E T ET, Meijer, J J and Omiecinski, C J CJ. 2000-09-15 Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms. [PMID:10862610] |
| 2.Farin, F M FM and 10 more authors. 2001-11 Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. [PMID:11692079] |
| 3.Wistow, Graeme G and 8 more authors. 2002-06-15 Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. [PMID:12107410] |
| 4.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932] |
| 5.Cronin, Annette A and 7 more authors. 2003-02-18 The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase. [PMID:12574508] |
| 6.Newman, John W JW, Morisseau, Christophe C, Harris, Todd R TR and Hammock, Bruce D BD. 2003-02-18 The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. [PMID:12574510] |
| 7.Petruzzelli, S S and 6 more authors. 1992-03 Cigarette smoke inhibits cytosolic but not microsomal epoxide hydrolase of human lung. [PMID:1349227] |
| 8.Papadopoulos, D D, Gröndal, S S, Rydström, J J and DePierre, J W JW. 1992-05 Levels of cytochrome P-450, steroidogenesis and microsomal and cytosolic epoxide hydrolases in normal human adrenal tissue and corresponding tumors. [PMID:1423213] |
| 9.Yoshimura, Kimio K and 8 more authors. 2003 Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples. [PMID:14634838] |
| 10.Sato, Keiko K and 12 more authors. 2004 Soluble epoxide hydrolase variant (Glu287Arg) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia: intrafamilial association study in an eight-generation hyperlipidemic kindred. [PMID:14673705] |