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IL4

DescriptionInterleukin-4

Gene and Protein Information

Gene ID3565
Uniprot Accession IDs Q14630 Q6NZ77 IL-4
Ensembl ID ENSP00000231449
Symbol BSF1 IL-4 BCGF1 BSF-1 BCGF-1
FamilyBelongs to the IL-4/IL-13 family.
Sequence
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp449565IL4interleukin 49598VGNC:4046Inparanoid, OMA, EggNOG
Macaque574281IL4interleukin 49544Inparanoid, OMA, EggNOG
Mouse16189Il4interleukin 410090MGI:96556Inparanoid, OMA, EggNOG
Rat287287Il4interleukin 410116RGD:2898Inparanoid, OMA, EggNOG
Dog403785IL4interleukin 49615VGNC:41987Inparanoid, OMA, EggNOG
Horse100034225IL4interleukin 49796Inparanoid, OMA, EggNOG
Cow280824IL4interleukin 49913VGNC:30161Inparanoid, OMA, EggNOG
Pig397225IL4interleukin 49823Inparanoid, OMA, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Hage, T T, Sebald, W W and Reinemer, P P. 1999-04-16 Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. [PMID:10219247]
      2.Sherman, M A MA, Nachman, T Y TY and Brown, M A MA. 1999-08-15 Cutting edge: IL-4 production by mast cells does not require c-maf. [PMID:10438901]
      3.Sakkas, L I LI, Tourtellotte, C C, Berney, S S, Myers, A R AR and Platsoucas, C D CD. 1999-09 Increased levels of alternatively spliced interleukin 4 (IL-4delta2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosis. [PMID:10473513]
      4.Bonecchi, R R and 12 more authors. 2000-04-01 Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes. [PMID:10725748]
      5.Loots, G G GG and 6 more authors. 2000-04-07 Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. [PMID:10753117]
      6.Mozzato-Chamay, N N and 5 more authors. 2000-11 Polymorphisms in candidate genes and risk of scarring trachoma in a Chlamydia trachomatis--endemic population. [PMID:11023480]
      7.Buchs, N N and 6 more authors. 2000-10 IL-4 VNTR gene polymorphism in chronic polyarthritis. The rare allele is associated with protection against destruction. [PMID:11035134]
      8.Suzuki, I I, Hizawa, N N, Yamaguchi, E E and Kawakami, Y Y. 2000-12 Association between a C+33T polymorphism in the IL-4 promoter region and total serum IgE levels. [PMID:11122213]
      9.Marone, G G, Florio, G G, Petraroli, A A and de Paulis, A A. 2001-01 Dysregulation of the IgE/Fc epsilon RI network in HIV-1 infection. [PMID:11149986]
      10.Torres-Galván, M J MJ and 8 more authors. 2001-02 IL4-R1 (5q31-q33) and FcepsilonRI-betaca (11q13) markers and atopy: a case/control study in a spanish population. [PMID:11167377]