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IKBKB

DescriptionInhibitor of nuclear factor kappa-B kinase subunit beta

Gene and Protein Information

Gene ID3551
Uniprot Accession IDs B4DZ30 B4E0U4 O75327 I-kappa-B-kinase beta
Ensembl ID ENSP00000430684
Symbol IKKB IKK2 IKKB IMD15 IMD15A IMD15B NFKBIKB IKK-beta
FamilyBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Sequence
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPEPAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Macaque704683IKBKBinhibitor of nuclear factor kappa B kinase subunit beta9544Inparanoid, EggNOG
Mouse16150Ikbkbinhibitor of kappaB kinase beta10090MGI:1338071Inparanoid, EggNOG
Rat84351Ikbkbinhibitor of nuclear factor kappa B kinase subunit beta10116RGD:621375Inparanoid, EggNOG
Dog482839IKBKBinhibitor of nuclear factor kappa B kinase subunit beta9615VGNC:51803Inparanoid, EggNOG
Cow281854IKBKBinhibitor of nuclear factor kappa B kinase subunit beta9913Inparanoid, EggNOG
Pig100101471IKBKBinhibitor of nuclear factor kappa B kinase subunit beta9823Inparanoid, EggNOG
Opossum100033031IKBKBinhibitor of nuclear factor kappa B kinase subunit beta13616Inparanoid, EggNOG
Platypus100078925IKBKBinhibitor of nuclear factor kappa B kinase subunit beta9258Inparanoid, EggNOG

Protein Classes

PANTHER Classes
protein    /    non-receptor serine/threonine protein kinase    /    Inhibitor of nuclear factor kappa-b kinase subunit beta
protein    /    protein kinase    /    Inhibitor of nuclear factor kappa-b kinase subunit beta
protein    /    transferase    /    Inhibitor of nuclear factor kappa-b kinase subunit beta
protein    /    kinase    /    Inhibitor of nuclear factor kappa-b kinase subunit beta
DTO Classes
protein    /    Kinase    /    Protein kinase    /    Other group    /    IKK family    /    Inhibitor of nuclear factor kappa-b kinase subunit beta

Associated Antibodies

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NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      Immunodeficiency 150UniProt Disease
      Immunodeficiency 151MonarchMONDO:0014267
      astrocytoma3773Expression AtlasMONDO:0021636
      Astrocytoma, Pilocytic3186Expression AtlasMONDO:0016691
      ependymoma5607Expression AtlasMONDO:0021191
      Gaucher disease type 1253Expression AtlasMONDO:0018150
      glioblastoma5998Expression AtlasMONDO:0018177
      intraductal papillary-mucinous adenoma (IPMA)2987Expression AtlasMONDO:0004381
      intraductal papillary-mucinous carcinoma (IPMC)3017Expression AtlasMONDO:0004285
      intraductal papillary-mucinous neoplasm (IPMN)3325Expression AtlasMONDO:0004286

      Bibliography

      1.Lallena, M J MJ, Diaz-Meco, M T MT, Bren, G G, Payá, C V CV and Moscat, J J. 1999-03 Activation of IkappaB kinase beta by protein kinase C isoforms. [PMID:10022904]
      2.Delhase, M M, Hayakawa, M M, Chen, Y Y and Karin, M M. 1999-04-09 Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. [PMID:10195894]
      3.Sanz, L L, Sanchez, P P, Lallena, M J MJ, Diaz-Meco, M T MT and Moscat, J J. 1999-06-01 The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. [PMID:10356400]
      4.Heissmeyer, V V, Krappmann, D D, Wulczyn, F G FG and Scheidereit, C C. 1999-09-01 NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. [PMID:10469655]
      5.Romashkova, J A JA and Makarov, S S SS. 1999-09-02 NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. [PMID:10485711]
      6.Sakurai, H H, Chiba, H H, Miyoshi, H H, Sugita, T T and Toriumi, W W. 1999-10-22 IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. [PMID:10521409]
      7.Hehner, S P SP and 8 more authors. 2000-04 Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex. [PMID:10713178]
      8.Aguirre, V V, Uchida, T T, Yenush, L L, Davis, R R and White, M F MF. 2000-03-24 The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). [PMID:10722755]
      9.Gil, J J, Alcamí, J J and Esteban, M M. 2000-03-09 Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex. [PMID:10723127]
      10.McKenzie, F R FR and 5 more authors. 2000-04 Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements. [PMID:10733566]