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HMGCR
| Description | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
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Gene and Protein Information
| Gene ID | 3156 |
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| Uniprot Accession IDs | B7Z3Y9 Q8N190 HMG-CoA reductase |
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| Ensembl ID | ENSP00000287936 |
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| Symbol | LDLCQ3 |
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| Family | Belongs to the HMG-CoA reductase family. |
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| Sequence | MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA Show more |
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Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
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| Chimp | 471516 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 9598 | VGNC:4034 | OMA, EggNOG |
| Macaque | 705479 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 9544 | | Inparanoid, OMA, EggNOG |
| Mouse | 15357 | Hmgcr | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 10090 | MGI:96159 | Inparanoid, OMA, EggNOG |
| Rat | 25675 | Hmgcr | 3-hydroxy-3-methylglutaryl-CoA reductase | 10116 | RGD:2803 | Inparanoid, OMA, EggNOG |
| Dog | 479182 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 9615 | VGNC:41714 | Inparanoid, OMA, EggNOG |
| Horse | 100065577 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 9796 | VGNC:18807 | Inparanoid, OMA, EggNOG |
| Cow | 407159 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 9913 | VGNC:29879 | Inparanoid, OMA, EggNOG |
| Pig | 100144446 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 9823 | | Inparanoid, OMA, EggNOG |
| Opossum | 100014439 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 13616 | | Inparanoid, OMA, EggNOG |
| Platypus | 100086613 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 9258 | | Inparanoid, OMA, EggNOG |
| Chicken | 395145 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 9031 | CGNC:11100 | Inparanoid, OMA, EggNOG |
| Anole lizard | 100555648 | hmgcr | 3-hydroxy-3-methylglutaryl-CoA reductase | 28377 | | Inparanoid, OMA, EggNOG |
| Xenopus | 100380121 | hmgcr | 3-hydroxy-3-methylglutaryl-CoA reductase | 8364 | XB-GENE-5840593 | Inparanoid, OMA, EggNOG |
| Zebrafish | 559054 | hmgcra | 3-hydroxy-3-methylglutaryl-CoA reductase a | 7955 | ZDB-GENE-040401-2 | Inparanoid, OMA, EggNOG |
| C. elegans | 176047 | hmgr-1 | 3-hydroxy-3-methylglutaryl coenzyme A reductase | 6239 | | Inparanoid, EggNOG |
| Fruitfly | 42803 | Hmgcr | HMG Coenzyme A reductase | 7227 | FBgn0263782 | Inparanoid, EggNOG |
| S.cerevisiae | 851171 | HMG2 | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 | 4932 | S000004442 | Inparanoid, EggNOG |
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Activity | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | species | Application | View Details |
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Associated Approved Drugs
Associated Active Ligands
Pathway
| Data Source | Name | Explore more targets | Explore in Source |
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