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| Description | Growth hormone receptor |
|---|
Gene and Protein Information
| Gene ID | 2690 |
|---|---|
| Uniprot Accession IDs | P10912 Q9HCX2 GH receptor |
| Ensembl ID | ENSP00000483403 |
| Symbol | GHBP GHIP |
| Family | Belongs to the type I cytokine receptor family. Type 1 subfamily. |
| Sequence | MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGEADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP Show more |
Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
|---|---|---|---|---|---|---|
| Chimp | 471560 | GHR | growth hormone receptor | 9598 | VGNC:4013 | OMA, EggNOG |
| Macaque | 697986 | GHR | growth hormone receptor | 9544 | Inparanoid, OMA, EggNOG | |
| Mouse | 14600 | Ghr | growth hormone receptor | 10090 | MGI:95708 | Inparanoid, OMA, EggNOG |
| Rat | 25235 | Ghr | growth hormone receptor | 10116 | RGD:2687 | Inparanoid, OMA, EggNOG |
| Dog | 403721 | GHR | growth hormone receptor | 9615 | VGNC:41206 | Inparanoid, OMA, EggNOG |
| Horse | 100053020 | GHR | growth hormone receptor | 9796 | VGNC:18333 | Inparanoid, OMA, EggNOG |
| Cow | 280805 | GHR | growth hormone receptor | 9913 | VGNC:50184 | Inparanoid, OMA, EggNOG |
| Pig | 397488 | GHR | growth hormone receptor | 9823 | Inparanoid, OMA, EggNOG | |
| Opossum | 554180 | GHR | growth hormone receptor | 13616 | Inparanoid, OMA, EggNOG | |
| Chicken | 408184 | GHR | growth hormone receptor | 9031 | CGNC:11022 | Inparanoid, OMA |
| Anole lizard | 100565883 | ghr | growth hormone receptor | 28377 | Inparanoid, OMA, EggNOG | |
| Xenopus | 100493377 | ghr | growth hormone receptor | 8364 | XB-GENE-481436 | Inparanoid, OMA, EggNOG |
| Zebrafish | 100001424 | ghra | growth hormone receptor a | 7955 | ZDB-GENE-070509-1 | Inparanoid, OMA, EggNOG |
Protein Classes
PANTHER Classes
protein / signaling molecule / defense/immunity protein / Growth hormone receptor
protein / signaling molecule / cytokine / Growth hormone receptor
protein / signaling molecule / defense/immunity protein / Growth hormone receptor
protein / signaling molecule / cytokine / Growth hormone receptor
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Availability | View Details |
|---|
Associated Antibodies
| Name | Specifications | Species reactivity | Application | Availability | View Details |
|---|
Associated Approved Drugs
Associated Active Ligands
Associated Diseases
| Name | Direct Associated Targets | Disease Type | Mondoid |
|---|---|---|---|
| Laron syndrome | 1 | UniProt Disease | MONDO:0009877 |
| Growth hormone insensitivity, partial | 0 | UniProt Disease | |
| Hypercholesterolemia, Familial | 9 | Monarch | MONDO:0007750 |
| Laron-type isolated somatotropin defect | 1 | Monarch | MONDO:0009877 |
| Short stature due to partial GHR deficiency | 3 | Monarch | MONDO:0011420 |
| active ulcerative colitis | 2513 | Expression Atlas | MONDO:0005101 |
| Astrocytoma, Pilocytic | 3186 | Expression Atlas | MONDO:0016691 |
| atopic dermatitis | 916 | Expression Atlas | MONDO:0004980 |
| breast cancer | 3880 | Expression Atlas | MONDO:0007254 |
| breast carcinoma | 2011 | Expression Atlas | MONDO:0004989 |
Bibliography
| 1.Cargill, M M and 17 more authors. 1999-07 Characterization of single-nucleotide polymorphisms in coding regions of human genes. [PMID:10391209] |
| 2.Hellgren, G G, Jansson, J O JO, Carlsson, L M LM and Carlsson, B B. 1999-06 The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver. [PMID:10502458] |
| 3.Vleurick, L L, Pezet, A A, Kühn, E R ER, Decuypere, E E and Edery, M M. 1999-11 A beta-turn endocytic code is required for optimal internalization of the growth hormone receptor but not for alpha-adaptin association. [PMID:10551776] |
| 4.Lee, S K SK and 14 more authors. 1999-11-26 A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. [PMID:10567404] |
| 5.Ram, P A PA and Waxman, D J DJ. 1999-12-10 SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. [PMID:10585430] |
| 6.Rivers, C A CA and Norman, M R MR. 2000-02-25 The human growth hormone receptor gene - characterisation of the liver-specific promoter. [PMID:10715538] |
| 7.Pantel, J J and 5 more authors. 2000-06-23 Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution. [PMID:10764769] |
| 8.Mahajan, M A MA and Samuels, H H HH. 2000-07 A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. [PMID:10866662] |
| 9.Enberg, B B and 5 more authors. 2000-07 Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation. [PMID:10870033] |
| 10.Stofega, M R MR, Herrington, J J, Billestrup, N N and Carter-Su, C C. 2000-09 Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B. [PMID:10976913] |