CFTR

Description	Cystic fibrosis transmembrane conductance regulator

Gene and Protein Information

Gene ID	1080
Uniprot Accession IDs	Q20BG8 Q20BH2 Q2I0A1 Q2I102 CFTR
Ensembl ID	ENSP00000003084
Symbol	ABCC7 CF MRP7 ABC35 ABCC7 CFTR/MRP TNR-CFTR dJ760C5.1
Family	Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
Sequence	MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQMNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQGQNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL Show more

Homologous gene and protein info.

Species	Gene ID	Gene Symbol	Name	Tax ID	Other Gene ID	Sources
Chimp	463674	CFTR	cystic fibrosis transmembrane conductance regulator	9598		Inparanoid, OMA, EggNOG
Macaque	574346	CFTR	cystic fibrosis transmembrane conductance regulator	9544		Inparanoid, OMA, EggNOG
Mouse	12638	Cftr	cystic fibrosis transmembrane conductance regulator	10090	MGI:88388	Inparanoid, OMA, EggNOG
Rat	24255	Cftr	cystic fibrosis transmembrane conductance regulator	10116	RGD:2332	Inparanoid, OMA
Dog	492302	CFTR	cystic fibrosis transmembrane conductance regulator	9615	VGNC:39180	Inparanoid, OMA, EggNOG
Horse	100071259	CFTR	cystic fibrosis transmembrane conductance regulator	9796	VGNC:16468	Inparanoid, OMA, EggNOG
Cow	281067	CFTR	cystic fibrosis transmembrane conductance regulator	9913	VGNC:50053	Inparanoid, OMA, EggNOG
Pig	403154	CFTR	cystic fibrosis transmembrane conductance regulator	9823		Inparanoid, OMA, EggNOG
Opossum	100014119	CFTR	cystic fibrosis transmembrane conductance regulator	13616		Inparanoid, OMA, EggNOG
Anole lizard	100559531	cftr	cystic fibrosis transmembrane conductance regulator	28377		Inparanoid, OMA, EggNOG
Xenopus	100486085	cftr	cystic fibrosis transmembrane conductance regulator	8364	XB-GENE-853972	Inparanoid, OMA, EggNOG
Zebrafish	559080	cftr	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	7955	ZDB-GENE-050517-20	Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein / transporter / ATP-binding cassette (ABC) transporter / Cystic fibrosis transmembrane conductance regulator

DTO Classes
protein / Ion channel / ABCC family / CFTR transporter subfamily / Cystic fibrosis transmembrane conductance regulator

Associated Recombinant Proteins

Name	Specification and purity	Expression system	Protein label	Activity	View Details

Associated Antibodies

Name	Specifications	Species reactivity	species	Application	View Details

Associated Approved Drugs

Associated Active Ligands

Associated Diseases

Name	Disease Type	Mondoid

Pathway

Data Source	Name	Explore more targets	Explore in Source