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PRKAR1A

DescriptioncAMP-dependent protein kinase type I-alpha regulatory subunit

Gene and Protein Information

Gene ID5573
Uniprot Accession IDs K7ER48 Q567S7
Ensembl ID ENSP00000376475
Symbol PKR1 PRKAR1 TSE1 CAR CNC CNC1 PKR1 TSE1 ADOHR PPNAD1 PRKAR1 ACRDYS1
FamilyBelongs to the cAMP-dependent kinase regulatory chain family.
Sequence
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp454845PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha9598VGNC:12609OMA, EggNOG
Macaque719021PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha9544OMA, EggNOG
Mouse19084Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha10090MGI:104878Inparanoid, OMA, EggNOG
Rat25725Prkar1aprotein kinase cAMP-dependent type 1 regulatory subunit alpha10116RGD:3391Inparanoid, OMA, EggNOG
Dog480459PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha9615VGNC:54342Inparanoid, OMA
Horse100053143PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha9796VGNC:21842Inparanoid, OMA
Cow615074PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha9913VGNC:33324Inparanoid, OMA
Pig397091PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha9823Inparanoid, OMA
Opossum100029185PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha13616Inparanoid, OMA
Platypus100078562PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha9258Inparanoid, OMA
Chicken417438PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha9031CGNC:3113Inparanoid, OMA
Anole lizard100554506prkar1aprotein kinase cAMP-dependent type I regulatory subunit alpha28377Inparanoid, OMA
Zebrafish494533prkar1aaprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a7955ZDB-GENE-050116-2Inparanoid, OMA
C. elegans180864kin-2cAMP-dependent protein kinase regulatory subunit6239Inparanoid, OMA

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

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NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Bibliography

      1.Zimmermann, B B, Chiorini, J A JA, Ma, Y Y, Kotin, R M RM and Herberg, F W FW. 1999-02-26 PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I. [PMID:10026146]
      2.Laxminarayana, D D and 5 more authors. 1999-05-01 Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes. [PMID:10228048]
      3.Herberg, F W FW, Maleszka, A A, Eide, T T, Vossebein, L L and Tasken, K K. 2000-04-28 Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding. [PMID:10764601]
      4.Reinton, N N and 6 more authors. 2000-07-01 Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. [PMID:10864471]
      5.Küssel-Andermann, P P and 6 more authors. 2000-09-22 Unconventional myosin VIIA is a novel A-kinase-anchoring protein. [PMID:10889203]
      6.Kirschner, L S LS and 7 more authors. 2000-09 Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. [PMID:10973256]
      7.Casey, M M and 9 more authors. 2000-09 Mutations in the protein kinase A R1alpha regulatory subunit cause familial cardiac myxomas and Carney complex. [PMID:10974026]
      8.Kirschner, L S LS and 5 more authors. 2000-12-12 Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex. [PMID:11115848]
      9.Simpson, J C JC, Wellenreuther, R R, Poustka, A A, Pepperkok, R R and Wiemann, S S. 2000-09 Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. [PMID:11256614]
      10.Fax, P P and 5 more authors. 2001-06-20 Binding of PKA-RIIalpha to the Adenovirus E1A12S oncoprotein correlates with its nuclear translocation and an increase in PKA-dependent promoter activity. [PMID:11414803]