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PRKAR2A

DescriptioncAMP-dependent protein kinase type II-alpha regulatory subunit

Gene and Protein Information

Gene ID5576
Uniprot Accession IDs Q16823 Q9BUB1
Ensembl ID ENSP00000265563
Symbol PKR2 PRKAR2 PKR2 PRKAR2
FamilyBelongs to the cAMP-dependent kinase regulatory chain family.
Sequence
MSHIQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGPDRVADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEACKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVGQYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLKSLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIARCHKGQYFGELALVTNKPRAASAYAVGDVKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKMFGSSVDLGNLGQ
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp100613657PRKAR2Aprotein kinase cAMP-dependent type II regulatory subunit alpha9598VGNC:12132OMA, EggNOG
Macaque708981LOC708981cAMP-dependent protein kinase type II-alpha regulatory subunit9544Inparanoid, OMA, EggNOG
Mouse19087Prkar2aprotein kinase, cAMP dependent regulatory, type II alpha10090MGI:108025Inparanoid, OMA, EggNOG
Rat29699Prkar2aprotein kinase cAMP-dependent type 2 regulatory subunit alpha10116RGD:3393Inparanoid, OMA, EggNOG
Dog100685147PRKAR2Aprotein kinase cAMP-dependent type II regulatory subunit alpha9615VGNC:44976Inparanoid, OMA
Cow100139910PRKAR2Aprotein kinase cAMP-dependent type II regulatory subunit alpha9913VGNC:33325Inparanoid, OMA, EggNOG
Pig397493PRKAR2Aprotein kinase cAMP-dependent type II regulatory subunit alpha9823OMA, EggNOG
Opossum100027250PRKAR2Aprotein kinase cAMP-dependent type II regulatory subunit alpha13616Inparanoid, OMA
Chicken100858827PRKAR2Aprotein kinase cAMP-dependent type II regulatory subunit alpha9031CGNC:64276OMA, EggNOG
Anole lizard100557810prkar2aprotein kinase cAMP-dependent type II regulatory subunit alpha28377Inparanoid, OMA
Xenopus100486265prkar2aprotein kinase, cAMP-dependent, regulatory subunit type II alpha8364XB-GENE-982783Inparanoid, OMA, EggNOG
Zebrafish556042prkar2aaprotein kinase, cAMP-dependent, regulatory, type II, alpha A7955ZDB-GENE-030131-1007Inparanoid, OMA
Fruitfly36041Pka-R2Protein kinase, cAMP-dependent, regulatory subunit type 27227FBgn0022382OMA, EggNOG

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
      group 3 medulloblastoma7142Expression AtlasMONDO:0007959
      medulloblastoma, large-cell6269Expression AtlasMONDO:0002791
      osteosarcoma7970Expression AtlasMONDO:0009807
      ovarian cancer8576Expression AtlasMONDO:0008170
      pancreatic ductal adenocarcinoma liver metastasis3122Expression AtlasMONDO:0005184
      psoriasis6696Expression AtlasMONDO:0005083
      subependymal giant cell astrocytoma2343Expression AtlasMONDO:0016693
      Endogenous depression0JensenLab Experiment TIGA
      Myocardial infarction0JensenLab Experiment TIGA

      Bibliography

      1.Zimmermann, B B, Chiorini, J A JA, Ma, Y Y, Kotin, R M RM and Herberg, F W FW. 1999-02-26 PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I. [PMID:10026146]
      2.Laxminarayana, D D and 5 more authors. 1999-05-01 Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes. [PMID:10228048]
      3.Vijayaraghavan, S S and 5 more authors. 1999-05 Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. [PMID:10319321]
      4.Takahashi, M M and 5 more authors. 1999-06-11 Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus. [PMID:10358086]
      5.Kapiloff, M S MS, Schillace, R V RV, Westphal, A M AM and Scott, J D JD. 1999-08 mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes. [PMID:10413680]
      6.Collas, P P, Le Guellec, K K and Taskén, K K. 1999-12-13 The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis. [PMID:10601332]
      7.Herberg, F W FW, Maleszka, A A, Eide, T T, Vossebein, L L and Tasken, K K. 2000-04-28 Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding. [PMID:10764601]
      8.Sun, F F, Hug, M J MJ, Bradbury, N A NA and Frizzell, R A RA. 2000-05-12 Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin. [PMID:10799517]
      9.Marx, S O SO and 6 more authors. 2000-05-12 PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. [PMID:10830164]
      10.Westphal, R S RS, Soderling, S H SH, Alto, N M NM, Langeberg, L K LK and Scott, J D JD. 2000-09-01 Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. [PMID:10970852]