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PRKACB

DescriptioncAMP-dependent protein kinase catalytic subunit beta

Gene and Protein Information

Gene ID5567
Uniprot Accession IDs B1APG4 B4DKB0 B4E2Q1 Q14VH1 Q59GC0 Q5BNE9 Q5BNF0 Q5BNF1 Q5BNF2 Q5BNF3 Q5CZ92 Q5T1K3 Q7Z3M1 Q8IYR5 Q8IZQ0 Q96B09 PKA C-beta
Ensembl ID ENSP00000359719
Symbol PKACB PKA C-beta
FamilyBelongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Sequence
MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp469367PRKACBprotein kinase cAMP-activated catalytic subunit beta9598VGNC:11804OMA, EggNOG
Macaque709728PRKACBprotein kinase cAMP-activated catalytic subunit beta9544Inparanoid, OMA, EggNOG
Mouse18749Prkacbprotein kinase, cAMP dependent, catalytic, beta10090MGI:97594Inparanoid, OMA, EggNOG
Rat293508Prkacbprotein kinase cAMP-activated catalytic subunit beta10116RGD:1310574Inparanoid, OMA, EggNOG
Dog479975PRKACBprotein kinase cAMP-activated catalytic subunit beta9615VGNC:44971Inparanoid, OMA, EggNOG
Horse100052828PRKACBprotein kinase cAMP-activated catalytic subunit beta9796VGNC:21838Inparanoid, OMA, EggNOG
Cow282323PRKACBprotein kinase cAMP-activated catalytic subunit beta9913VGNC:33321Inparanoid, OMA
Opossum100011211PRKACBprotein kinase cAMP-activated catalytic subunit beta13616Inparanoid, OMA
Zebrafish563147prkacbbprotein kinase, cAMP-dependent, catalytic, beta b7955ZDB-GENE-050904-4Inparanoid, OMA
Fruitfly34284Pka-C1Protein kinase, cAMP-dependent, catalytic subunit 17227FBgn0000273OMA, EggNOG
S.cerevisiae853275TPK1cAMP-dependent protein kinase catalytic subunit TPK14932S000003700OMA, EggNOG

Protein Classes

DTO Classes
protein    /    Kinase    /    Protein kinase    /    AGC group    /    PKA family    /    Camp-dependent protein kinase catalytic subunit beta

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Hartley, J L JL, Temple, G F GF and Brasch, M A MA. 2000-11 DNA cloning using in vitro site-specific recombination. [PMID:11076863]
      2.Jiang, C H CH, Tsien, J Z JZ, Schultz, P G PG and Hu, Y Y. 2001-02-13 The effects of aging on gene expression in the hypothalamus and cortex of mice. [PMID:11172053]
      3.Ørstavik, S S and 5 more authors. 2001-10 Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase. [PMID:11589697]
      4.Wu, Kou-Juey KJ, Mattioli, Michela M, Morse, Herbert C HC and Dalla-Favera, Riccardo R. 2002-11-07 c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cbeta) gene. [PMID:12420224]
      5.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      6.Vermeulen, Linda L, De Wilde, Gert G, Van Damme, Petra P, Vanden Berghe, Wim W and Haegeman, Guy G. 2003-03-17 Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). [PMID:12628924]
      7.Higuchi, Haruhisa H, Yamashita, Toshihide T, Yoshikawa, Hideki H and Tohyama, Masaya M. 2003-04-15 PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts. [PMID:12682012]
      8.Gassel, Michael M and 7 more authors. 2003-06-20 Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT). [PMID:12798691]
      9.Cartier, Christine C and 6 more authors. 2003-09-12 Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein. [PMID:12842892]
      10.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039]