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TOP2B
| Description | DNA topoisomerase 2-beta |
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Gene and Protein Information
| Gene ID | 7155 |
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| Uniprot Accession IDs | Q13600 Q9UMG8 Q9UQP8 |
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| Ensembl ID | ENSP00000396704 |
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| Symbol | TOPIIB top2beta |
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| Family | Belongs to the type II topoisomerase family. |
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| Sequence | MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMFN Show more |
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Homologous gene and protein info.
| Species | Gene ID | Gene Symbol | Name | Tax ID | Other Gene ID | Sources |
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| Chimp | 460232 | TOP2B | DNA topoisomerase II beta | 9598 | VGNC:8848 | OMA, EggNOG |
| Macaque | 677709 | TOP2B | DNA topoisomerase II beta | 9544 | | Inparanoid, OMA, EggNOG |
| Mouse | 21974 | Top2b | topoisomerase (DNA) II beta | 10090 | MGI:98791 | Inparanoid, OMA, EggNOG |
| Dog | 477044 | TOP2B | DNA topoisomerase II beta | 9615 | VGNC:49632 | Inparanoid, OMA, EggNOG |
| Horse | 100059572 | TOP2B | DNA topoisomerase II beta | 9796 | VGNC:50517 | Inparanoid, OMA, EggNOG |
| Cow | 282097 | TOP2B | DNA topoisomerase II beta | 9913 | VGNC:49158 | Inparanoid, OMA, EggNOG |
| Pig | 100156319 | TOP2B | DNA topoisomerase II beta | 9823 | | OMA, EggNOG |
| Opossum | 100031654 | TOP2B | DNA topoisomerase II beta | 13616 | | Inparanoid, OMA, EggNOG |
| Platypus | 100075740 | TOP2B | DNA topoisomerase II beta | 9258 | | Inparanoid, OMA, EggNOG |
| Anole lizard | 100563490 | top2b | DNA topoisomerase II beta | 28377 | | Inparanoid, OMA |
| Xenopus | 779457 | top2b | DNA topoisomerase II beta | 8364 | XB-GENE-940716 | Inparanoid, OMA |
| Xenopus | 100038293 | top2a | DNA topoisomerase II alpha | 8364 | XB-GENE-970178 | OMA, EggNOG |
| Zebrafish | 569877 | top2b | DNA topoisomerase II beta | 7955 | ZDB-GENE-041008-136 | Inparanoid, OMA, EggNOG |
| C. elegans | 174825 | top-2 | Probable DNA topoisomerase 2 | 6239 | | Inparanoid, OMA |
| Fruitfly | 35225 | Top2 | Topoisomerase 2 | 7227 | FBgn0284220 | Inparanoid, OMA, EggNOG |
| S.cerevisiae | 855636 | TOP2 | DNA topoisomerase 2 | 4932 | S000005032 | Inparanoid, OMA, EggNOG |
Associated Recombinant Proteins
| Name | Specification and purity | Expression system | Protein label | Activity | View Details |
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Associated Antibodies
| Name | Specifications | Species reactivity | species | Application | View Details |
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Associated Approved Drugs
Associated Active Ligands
Pathway
| Data Source | Name | Explore more targets | Explore in Source |
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