Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

EGF

DescriptionPro-epidermal growth factor

Gene and Protein Information

Gene ID1950
Uniprot Accession IDs B4DRK7 E7EVD2 E9PBF0 Q52LZ6 EGF
Ensembl ID ENSP00000265171
Symbol URG HOMG4
Sequence
MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ
Show more
Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp461435EGFepidermal growth factor9598VGNC:10856OMA, EggNOG
Macaque698619EGFepidermal growth factor9544Inparanoid, OMA, EggNOG
Mouse13645Egfepidermal growth factor10090MGI:95290Inparanoid, OMA, EggNOG
Dog403657EGFepidermal growth factor9615VGNC:40235Inparanoid, OMA, EggNOG
Horse106782874EGFepidermal growth factor9796VGNC:17456Inparanoid, OMA, EggNOG
Opossum100619143EGFepidermal growth factor13616Inparanoid, OMA, EggNOG
Chicken408035EGFepidermal growth factor9031CGNC:9223Inparanoid, OMA, EggNOG
Anole lizardEGFepidermal growth factor [Source:HGNC Symbol;Acc:HGNC:3229]28377Inparanoid, OMA
Xenopus100127663egfepidermal growth factor8364XB-GENE-951823Inparanoid, OMA, EggNOG
Zebrafish403045egfepidermal growth factor7955ZDB-GENE-070922-1Inparanoid, OMA, EggNOG

Associated Recombinant Proteins

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      Hypomagnesemia 40UniProt Disease
      renal hypomagnesemia 41MonarchMONDO:0012717
      breast cancer3880Expression AtlasMONDO:0007254
      gastric cancer734Expression AtlasMONDO:0001056
      gastric cancer1287Expression AtlasMONDO:0004950
      hepatocellular carcinoma980Expression AtlasMONDO:0007256
      intraductal papillary-mucinous adenoma (IPMA)2987Expression AtlasMONDO:0004381
      intraductal papillary-mucinous carcinoma (IPMC)3017Expression AtlasMONDO:0004285
      intraductal papillary-mucinous neoplasm (IPMN)3325Expression AtlasMONDO:0004286
      lung adenocarcinoma2873Expression AtlasMONDO:0005061

      Bibliography

      1.Edmondson, S R SR, Murashita, M M MM, Russo, V C VC, Wraight, C J CJ and Werther, G A GA. 1999-05 Expression of insulin-like growth factor binding protein-3 (IGFBP-3) in human keratinocytes is regulated by EGF and TGFbeta1. [PMID:10199559]
      2.Sassone-Corsi, P P and 7 more authors. 1999-08-06 Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. [PMID:10436156]
      3.Keely, S J SJ and Barrett, K E KE. 1999-11-19 ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells. [PMID:10559227]
      4.Rosenthal, J A JA and 6 more authors. 1999-11-26 The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. [PMID:10567358]
      5.Adam, R M RM and 5 more authors. 1999-12 Amphiregulin is coordinately expressed with heparin-binding epidermal growth factor-like growth factor in the interstitial smooth muscle of the human prostate. [PMID:10579352]
      6.Rodrigues, G A GA, Falasca, M M, Zhang, Z Z, Ong, S H SH and Schlessinger, J J. 2000-02 A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. [PMID:10648629]
      7.Gual, P P and 5 more authors. 2000-03-16 Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis. [PMID:10734310]
      8.Pahl, P M PM and 5 more authors. 2000-06-09 An exochelin of Mycobacterium tuberculosis reversibly arrests growth of human vascular smooth muscle cells in vitro. [PMID:10748174]
      9.Stang, E E, Johannessen, L E LE, Knardal, S L SL and Madshus, I H IH. 2000-05-05 Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation. [PMID:10788520]
      10.Lock, L S LS, Royal, I I, Naujokas, M A MA and Park, M M. 2000-10-06 Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases. [PMID:10913131]