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SIRT6

DescriptionNAD-dependent protein deacetylase sirtuin-6

Gene and Protein Information

Gene ID51548
Uniprot Accession IDs B2RCD0 O75291 Q6IAF5 Q6PK99 Q8NCD2 Q9BSI5 Q9BWP3 Q9NRC7 Q9UQD1
Ensembl ID ENSP00000337332
Symbol SIR2L6 SIR2L6
FamilyBelongs to the sirtuin family. Class IV subfamily.
Sequence
MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp737026SIRT6sirtuin 69598VGNC:12101OMA, EggNOG
Macaque714545SIRT6sirtuin 69544Inparanoid, OMA, EggNOG
Mouse50721Sirt6sirtuin 610090MGI:1354161Inparanoid, OMA, EggNOG
Rat299638Sirt6sirtuin 610116RGD:1305216Inparanoid, OMA, EggNOG
Dog485045SIRT6sirtuin 69615VGNC:46187Inparanoid, OMA, EggNOG
Cow535416SIRT6sirtuin 69913VGNC:34635Inparanoid, OMA, EggNOG
Pig100126274SIRT6sirtuin 69823Inparanoid, OMA, EggNOG
Opossum100022578SIRT6sirtuin 613616Inparanoid, OMA, EggNOG
Platypus100091769SIRT6sirtuin 69258Inparanoid, OMA, EggNOG
Chicken428332SIRT6sirtuin 69031CGNC:850Inparanoid, OMA, EggNOG
Xenopus394980sirt6sirtuin 68364XB-GENE-5929105Inparanoid, OMA, EggNOG
C. elegans182284sir-2.4NAD-dependent protein deacetylase sir-2.46239Inparanoid, OMA, EggNOG
Fruitfly41254Sirt6Sirtuin 67227FBgn0037802Inparanoid, OMA, EggNOG

Protein Classes

DTO Classes
protein    /    Epigenetic regulator    /    Eraser    /    Histone deacetylase    /    HDAC class III    /    NAD-dependent protein deacetylase sirtuin-6

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
      glioblastoma5998Expression AtlasMONDO:0018177
      medulloblastoma, large-cell6269Expression AtlasMONDO:0002791
      ovarian cancer8576Expression AtlasMONDO:0008170
      Cardiomegaly0CTD
      Cardiomegaly0DisGeNET
      Cardiac Hypertrophy0DisGeNET
      Cancer0JensenLab Knowledge UniProtKB-KW
      DOID:00810620JensenLab Text Mining

      Bibliography

      1. and Frye, R A RA. 2000-07-05 Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. [PMID:10873683]
      2.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      3.Ota, Toshio T and 156 more authors. 2004-01 Complete sequencing and characterization of 21,243 full-length human cDNAs. [PMID:14702039]
      4.Grimwood, Jane J and 97 more authors. 2004-04-01 The DNA sequence and biology of human chromosome 19. [PMID:15057824]
      5.Brandenberger, Ralph R and 13 more authors. 2004-06 Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. [PMID:15146197]
      6.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334]
      7.Michishita, Eriko E, Park, Jean Y JY, Burneskis, Jenna M JM, Barrett, J Carl JC and Horikawa, Izumi I. 2005-10 Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. [PMID:16079181]
      8.Stelzl, Ulrich U and 22 more authors. 2005-09-23 A human protein-protein interaction network: a resource for annotating the proteome. [PMID:16169070]
      9.Rual, Jean-François JF and 37 more authors. 2005-10-20 Towards a proteome-scale map of the human protein-protein interaction network. [PMID:16189514]
      10.Yamamoto, Hiroyasu H, Schoonjans, Kristina K and Auwerx, Johan J. 2007-08 Sirtuin functions in health and disease. [PMID:17456799]