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RXRA

DescriptionRetinoic acid receptor RXR-alpha

Gene and Protein Information

Gene ID6256
Uniprot Accession IDs B3KY83 Q2NL52 Q2V504
Ensembl ID ENSP00000419692
Symbol NR2B1 NR2B1
FamilyBelongs to the nuclear hormone receptor family. NR2 subfamily.
Sequence
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Mouse20181Rxraretinoid X receptor alpha10090MGI:98214Inparanoid, OMA
Rat25271Rxraretinoid X receptor alpha10116RGD:3610Inparanoid, OMA
Dog491278RXRAretinoid X receptor alpha9615VGNC:45817Inparanoid, OMA
Horse100069096RXRAretinoid X receptor alpha9796VGNC:22639Inparanoid, OMA
Cow507554RXRAretinoid X receptor alpha9913VGNC:34230Inparanoid, OMA
Platypus100074625RXRAretinoid X receptor alpha9258Inparanoid, OMA
Chicken417143RXRAretinoid X receptor alpha9031CGNC:1890Inparanoid, OMA
Xenopus100487877rxraretinoid X receptor alpha8364XB-GENE-478718Inparanoid, OMA
Zebrafish555578rxraaretinoid X receptor, alpha a7955ZDB-GENE-070314-2Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    transcription factor    /    Retinoic acid receptor rxr-alpha
protein    /    receptor    /    Retinoic acid receptor rxr-alpha
protein    /    nucleic acid binding    /    Retinoic acid receptor rxr-alpha
protein    /    C4 zinc finger nuclear receptor    /    Retinoic acid receptor rxr-alpha
DTO Classes
protein    /    Nuclear receptor    /    Retinoid X receptors    /    Retinoic acid receptor rxr-alpha

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
Recombinant RXRA AntibodyHuman,Mouse,Rat
  • IF/ICC
  • WB
In stock
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Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      astrocytoma3773Expression AtlasMONDO:0021636
      chronic lymphocytic leukemia479Expression AtlasMONDO:0004948
      group 4 medulloblastoma7142Expression AtlasMONDO:0007959
      interstitial cystitis2307Expression AtlasMONDO:0018301
      invasive ductal carcinoma2965Expression AtlasMONDO:0004953
      lung carcinoma2913Expression AtlasMONDO:0005138
      medulloblastoma, large-cell6269Expression AtlasMONDO:0002791
      mucosa-associated lymphoid tissue lymphoma486Expression AtlasMONDO:0007650
      osteosarcoma7970Expression AtlasMONDO:0009807
      ovarian cancer8576Expression AtlasMONDO:0008170

      Bibliography

      1.Na, S Y SY and 8 more authors. 1999-03-19 Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB. [PMID:10075655]
      2.Miyamoto, T T, Kakizawa, T T and Hashizume, K K. 1999-04 Inhibition of nuclear receptor signalling by poly(ADP-ribose) polymerase. [PMID:10082530]
      3.Gorla-Bajszczak, A A, Juge-Aubry, C C, Pernin, A A, Burger, A G AG and Meier, C A CA. 1999-01-25 Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR. [PMID:10195690]
      4.Heinlein, C A CA, Ting, H J HJ, Yeh, S S and Chang, C C. 1999-06-04 Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma. [PMID:10347167]
      5.Suzuki, Y Y and 5 more authors. 1999-06-15 Physical interaction between retinoic acid receptor and Sp1: mechanism for induction of urokinase by retinoic acid. [PMID:10361124]
      6.Kakizawa, T T and 10 more authors. 1999-07-02 Functional interaction between Oct-1 and retinoid X receptor. [PMID:10383413]
      7.Roder, K K, Wolf, S S SS, Larkin, K J KJ and Schweizer, M M. 1999-06-24 Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1. [PMID:10393239]
      8.Nagpal, S S and 6 more authors. 1999-08-06 Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor. [PMID:10428834]
      9.Scorrano, L L, Petronilli, V V, Di Lisa, F F and Bernardi, P P. 1999-08-06 Commitment to apoptosis by GD3 ganglioside depends on opening of the mitochondrial permeability transition pore. [PMID:10428836]
      10.Li, D D and 5 more authors. 1999-10 NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors. [PMID:10490654]