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SLC6A2

DescriptionSodium-dependent noradrenaline transporter

Gene and Protein Information

Gene ID6530
Uniprot Accession IDs B2R707 B4DX48 Q96KH8
Ensembl ID ENSP00000219833
Symbol NAT1 NET1 SLC6A5 NET NAT1 NET1 SLC6A5
FamilyBelongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily.
Sequence
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp454096SLC6A2solute carrier family 6 member 29598VGNC:9017OMA, EggNOG
Macaque613238SLC6A2solute carrier family 6 member 29544Inparanoid, OMA, EggNOG
Mouse20538Slc6a2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 210090MGI:1270850Inparanoid, OMA, EggNOG
Rat83511Slc6a2solute carrier family 6 member 210116RGD:621822Inparanoid, OMA
Dog487272SLC6A2solute carrier family 6 member 29615VGNC:46462Inparanoid, OMA, EggNOG
Horse100061346SLC6A2solute carrier family 6 member 29796VGNC:23258Inparanoid, OMA, EggNOG
Cow282363SLC6A2solute carrier family 6 member 29913VGNC:34920Inparanoid, OMA, EggNOG
Pig100517716SLC6A2solute carrier family 6 member 29823OMA, EggNOG
Opossum100020675SLC6A2solute carrier family 6 member 213616Inparanoid, EggNOG
PlatypusSLC6A2solute carrier family 6 member 2 [Source:HGNC Symbol;Acc:HGNC:11048]9258OMA, EggNOG
Chicken395458SLC6A2solute carrier family 6 member 29031CGNC:49331Inparanoid, OMA, EggNOG
Anole lizard100557960slc6a2solute carrier family 6 member 228377Inparanoid, OMA, EggNOG
Xenopus100486589slc6a2solute carrier family 6 member 28364XB-GENE-486549Inparanoid, OMA, EggNOG
Zebrafish565776slc6a2solute carrier family 6 (neurotransmitter transporter), member 27955ZDB-GENE-110408-4Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    transporter    /    cation transporter    /    Sodium-dependent noradrenaline transporter
DTO Classes
protein    /    Transporter    /    SLC superfamily of solute carriers    /    SLC6 neurotransmitter transporter family    /    Monoamine transporter subfamily    /    Sodium-dependent noradrenaline transporter

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      Orthostatic intolerance0UniProt Disease
      Orthostatic Intolerance1MonarchMONDO:0011479
      osteosarcoma7970Expression AtlasMONDO:0009807
      Hypertension194CTDMONDO:0005044
      Orthostatic Intolerance0CTD
      Seizures101CTDMONDO:0001386
      mitral valve prolapse syndrome0eRAM
      mitral valve prolapse syndrome3eRAMMONDO:0004910
      orthostatic intolerance0eRAM
      Alcoholic Intoxication, Chronic0DisGeNET

      Bibliography

      1.Kim, C H CH, Kim, H S HS, Cubells, J F JF and Kim, K S KS. 1999-03-05 A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene. [PMID:10037744]
      2.Shannon, J R JR and 7 more authors. 2000-02-24 Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. [PMID:10684912]
      3.Torres, G E GE and 7 more authors. 2001-04 Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. [PMID:11343649]
      4. and Eisenhofer, G G. 2001-07 The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. [PMID:11707293]
      5.Paczkowski, F A FA and Bryan-Lluka, L J LJ. 2001-12-16 Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology. [PMID:11744160]
      6.Paczkowski, Filip A FA, Bönisch, Heinz H and Bryan-Lluka, Lesley J LJ. 2002-03 Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter. [PMID:11875370]
      7.Zill, Peter P and 13 more authors. 2002-04 Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression. [PMID:11927173]
      8.Leszczyńska-Rodziewicz, Anna A and 6 more authors. 2002 A polymorphism of the norepinephrine transporter gene in bipolar disorder and schizophrenia: lack of association. [PMID:12097806]
      9.Bauman, Patricia A PA and Blakely, Randy D RD. 2002-08-01 Determinants within the C-terminus of the human norepinephrine transporter dictate transporter trafficking, stability, and activity. [PMID:12127072]
      10.Urwin, R E RE and 8 more authors. 2002 Anorexia nervosa (restrictive subtype) is associated with a polymorphism in the novel norepinephrine transporter gene promoter polymorphic region. [PMID:12140790]