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SLC6A8

DescriptionSodium- and chloride-dependent creatine transporter 1

Gene and Protein Information

Gene ID6535
Uniprot Accession IDs B2KY47 B4DIA3 E9PFC0 Q13032 Q66I36 CT1
Ensembl ID ENSP00000253122
Symbol CRT CT1 CRTR CTR5 CCDS1
FamilyBelongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.
Sequence
MAKKSAENGIYSVSGDEKKGPLIAPGPDGAPAKGDGPVGLGTPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Macaque698307SLC6A8solute carrier family 6 member 89544Inparanoid, OMA
Mouse102857Slc6a8solute carrier family 6 (neurotransmitter transporter, creatine), member 810090MGI:2147834Inparanoid, OMA
Rat50690Slc6a8solute carrier family 6 member 810116RGD:619711Inparanoid, OMA
Dog492242SLC6A8solute carrier family 6 member 89615VGNC:54602Inparanoid, OMA
Horse100058799SLC6A8solute carrier family 6 member 89796Inparanoid, OMA
Cow282367SLC6A8solute carrier family 6 member 89913Inparanoid, OMA
Opossum100014962SLC6A8solute carrier family 6 member 813616Inparanoid, OMA
Anole lizard100561420slc6a8solute carrier family 6 member 828377Inparanoid, OMA
Zebrafish567544slc6a8solute carrier family 6 (neurotransmitter transporter), member 87955ZDB-GENE-071024-2Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    transporter    /    cation transporter    /    Sodium- and chloride-dependent creatine transporter 1
DTO Classes
protein    /    Transporter    /    SLC superfamily of solute carriers    /    SLC6 neurotransmitter transporter family    /    GABA transporter subfamily    /    Sodium- and chloride-dependent creatine transporter 1

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
SLC6A8 AntibodyHuman,Mouse,Rat
  • IHC
  • WB
Out of Stock
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Associated Approved Drugs

    Associated Active Ligands

      Bibliography

      1.Wyss, M M and Kaddurah-Daouk, R R. 2000-07 Creatine and creatinine metabolism. [PMID:10893433]
      2.Grunau, C C, Hindermann, W W and Rosenthal, A A. 2000-11-01 Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes. [PMID:11063724]
      3.Salomons, G S GS and 6 more authors. 2001-06 X-linked creatine-transporter gene (SLC6A8) defect: a new creatine-deficiency syndrome. [PMID:11326334]
      4.Hahn, Kimberly A KA and 11 more authors. 2002-05 X-linked mental retardation with seizures and carrier manifestations is caused by a mutation in the creatine-transporter gene (SLC6A8) located in Xq28. [PMID:11898126]
      5.Bizzi, Alberto A and 8 more authors. 2002-08 X-linked creatine deficiency syndrome: a novel mutation in creatine transporter gene SLC6A8. [PMID:12210795]
      6.Wang, Weiyang W, Shang, Li-Hong LH and Jacobs, Danny O DO. 2002-08 Complement regulatory protein CD59 involves c-SRC related tyrosine phosphorylation of the creatine transporter in skeletal muscle during sepsis. [PMID:12219031]
      7.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      8.Rosenberg, Efraim H EH and 11 more authors. 2004-07 High prevalence of SLC6A8 deficiency in X-linked mental retardation. [PMID:15154114]
      9. and Mandel, J L JL. 2004-10 Comparative frequency of fragile-X (FMR1) and creatine transporter (SLC6A8) mutations in X-linked mental retardation. [PMID:15338463]
      10.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334]