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SLC5A7

DescriptionHigh affinity choline transporter 1

Gene and Protein Information

Gene ID60482
Uniprot Accession IDs Q53TF2
Ensembl ID ENSP00000264047
Symbol CHT1 CHT CHT1 CMS20 HMN7A
FamilyBelongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Sequence
MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp470492SLC5A7solute carrier family 5 member 79598VGNC:7711OMA, EggNOG
Macaque714093SLC5A7solute carrier family 5 member 79544Inparanoid, OMA, EggNOG
Mouse63993Slc5a7solute carrier family 5 (choline transporter), member 710090MGI:1927126Inparanoid, OMA, EggNOG
Rat85426Slc5a7solute carrier family 5 member 710116RGD:69270Inparanoid, OMA, EggNOG
Dog481311SLC5A7solute carrier family 5 member 79615VGNC:46450Inparanoid, OMA, EggNOG
Horse100060334SLC5A7solute carrier family 5 member 79796VGNC:23248Inparanoid, OMA, EggNOG
Cow512311SLC5A7solute carrier family 5 member 79913VGNC:34910Inparanoid, OMA, EggNOG
Pig100512044SLC5A7solute carrier family 5 member 79823Inparanoid, OMA, EggNOG
Opossum100015069SLC5A7solute carrier family 5 member 713616Inparanoid, OMA, EggNOG
Chicken414870SLC5A7solute carrier family 5 member 79031CGNC:12606Inparanoid, OMA, EggNOG
Anole lizard100562419slc5a7solute carrier family 5 member 728377Inparanoid, OMA, EggNOG
Xenopus100490609slc5a7solute carrier family 5 (sodium/choline cotransporter), member 78364XB-GENE-961535Inparanoid, OMA
Zebrafish799259LOC799259high-affinity choline transporter 1-like7955Inparanoid, OMA
C. elegans178274cho-1High-affinity choline transporter 16239Inparanoid, OMA, EggNOG
Fruitfly42245CG7708CG7708 gene product from transcript CG7708-RB7227FBgn0038641Inparanoid, OMA, EggNOG

Protein Classes

DTO Classes
protein    /    Transporter    /    SLC superfamily of solute carriers    /    SLC5 family of sodium-dependent glucose transporters    /    Choline transporter    /    High affinity choline transporter 1

Associated Approved Drugs

    Associated Active Ligands

      Bibliography

      1.Apparsundaram, S S, Ferguson, S M SM, George, A L AL and Blakely, R D RD. 2000-10-05 Molecular cloning of a human, hemicholinium-3-sensitive choline transporter. [PMID:11027560]
      2.Okuda, T T and Haga, T T. 2000-11-03 Functional characterization of the human high-affinity choline transporter. [PMID:11068039]
      3.McEntagart, M M and 12 more authors. 2001-05 Localization of the gene for distal hereditary motor neuronopathy VII (dHMN-VII) to chromosome 2q14. [PMID:11294660]
      4.Okuda, Takashi T, Okamura, Michiko M, Kaitsuka, China C, Haga, Tatsuya T and Gurwitz, David D. 2002-11-22 Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate. [PMID:12237312]
      5.Haberberger, Rainer Viktor RV, Pfeil, Uwe U, Lips, Katrin Susanne KS and Kummer, Wolfgang W. 2002-10 Expression of the high-affinity choline transporter, CHT1, in the neuronal and non-neuronal cholinergic system of human and rat skin. [PMID:12406342]
      6.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      7.Pfeil, Uwe U and 5 more authors. 2003-03-28 Expression of the high-affinity choline transporter CHT1 in epithelia. [PMID:12628461]
      8.Ribeiro, F M FM and 10 more authors. 2003-10 The hemicholinium-3 sensitive high affinity choline transporter is internalized by clathrin-mediated endocytosis and is present in endosomes and synaptic vesicles. [PMID:12969261]
      9.Lips, Katrin S KS and 8 more authors. 2003-12 Expression of the high-affinity choline transporter CHT1 in rat and human arteries. [PMID:14623932]
      10.Xie, Jun J and Guo, Qing Q. 2004-07-02 Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. [PMID:15090548]