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SF3B3

DescriptionSplicing factor 3B subunit 3

Gene and Protein Information

Gene ID23450
Uniprot Accession IDs Q15393 Q6NTI8 Q96GC0 Q9BPY2 Q9UFX7 Q9UJ29
Ensembl ID ENSP00000305790
Symbol KIAA0017 SAP130 RSE1 SAP130 SF3b130 STAF130
FamilyBelongs to the RSE1 family.
Sequence
MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAAAFLNENLPESIFGAPKAGNGQWASVIRVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQGRVLIGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYPRWVTTASLLDYDTVAGADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHEDHDFFQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVIDGDLCEQFNSMEPNKQKNVSEELDRTPPEVSKKLEDIRTRYAF
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp454216SF3B3splicing factor 3b subunit 39598VGNC:5918OMA, EggNOG
Macaque708939SF3B3splicing factor 3b subunit 39544OMA, EggNOG
Mouse101943Sf3b3splicing factor 3b, subunit 310090MGI:1289341Inparanoid, OMA, EggNOG
Rat292019Sf3b3splicing factor 3b, subunit 310116RGD:1311636Inparanoid, OMA, EggNOG
Dog479659SF3B3splicing factor 3b subunit 39615VGNC:46071Inparanoid, OMA, EggNOG
Horse100054753SF3B3splicing factor 3b subunit 39796VGNC:22890Inparanoid, OMA, EggNOG
Cow504962SF3B3splicing factor 3b subunit 39913VGNC:34511Inparanoid, OMA, EggNOG
Opossum100024525SF3B3splicing factor 3b subunit 313616Inparanoid, EggNOG
Platypus100074472SF3B3splicing factor 3b subunit 39258Inparanoid, OMA, EggNOG
Chicken415680SF3B3splicing factor 3b subunit 39031CGNC:1817Inparanoid, OMA, EggNOG
Anole lizard100560403sf3b3splicing factor 3b subunit 328377Inparanoid, OMA, EggNOG
Xenopus100101755sf3b3splicing factor 3b subunit 38364XB-GENE-921994Inparanoid, OMA, EggNOG
Zebrafish406824sf3b3splicing factor 3b, subunit 37955ZDB-GENE-040426-2901Inparanoid, OMA
C. elegans172406teg-4Tumorous Enhancer of Glp-1(gf)6239Inparanoid, OMA, EggNOG
S.cerevisiae854956RSE1U2 snRNP complex subunit RSE14932S000004513Inparanoid, OMA, EggNOG

Protein Classes

PANTHER Classes
protein    /    nucleic acid binding    /    damaged DNA-binding protein    /    Splicing factor 3B subunit 3
protein    /    nucleic acid binding    /    mRNA polyadenylation factor    /    Splicing factor 3B subunit 3
protein    /    nucleic acid binding    /    mRNA splicing factor    /    Splicing factor 3B subunit 3
DTO Classes
protein    /    Nucleic acid binding    /    RNA binding protein    /    mRNA processing factor    /    mRNA splicing factor    /    Splicing factor 3B subunit 3

Associated Antibodies

NameSpecificationsSpecies reactivityApplicationAvailabilityView Details
Recombinant SF3B3 AntibodyHuman,Mouse,Rat
  • WB
Out of Stock
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Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid
      astrocytoma3773Expression AtlasMONDO:0021636
      atypical teratoid / rhabdoid tumor5491Expression AtlasMONDO:0020560
      colon cancer1587Expression AtlasMONDO:0021063
      lung cancer4468Expression AtlasMONDO:0008903
      medulloblastoma, large-cell6269Expression AtlasMONDO:0002791
      ovarian cancer8576Expression AtlasMONDO:0008170
      Atopic dermatitis0DrugCentral Indication
      Intractable Eczema0DrugCentral Indication
      Liver transplant rejection0DrugCentral Indication
      Prevention of Cardiac Transplant Rejection0DrugCentral Indication

      Bibliography

      1.Mintz, P J PJ, Patterson, S D SD, Neuwald, A F AF, Spahr, C S CS and Spector, D L DL. 1999-08-02 Purification and biochemical characterization of interchromatin granule clusters. [PMID:10428969]
      2.Das, B K BK and 5 more authors. 1999-10 Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. [PMID:10490618]
      3.Brand, M M and 7 more authors. 2001-06-15 UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. [PMID:11406595]
      4.Gangloff, Y G YG and 9 more authors. 2001-08 The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger. [PMID:11438666]
      5.Will, C L CL and 7 more authors. 2001-08-15 A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. [PMID:11500380]
      6.Martinez, E E and 7 more authors. 2001-10 Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. [PMID:11564863]
      7.Jurica, Melissa S MS, Licklider, Lawrence J LJ, Gygi, Steven R SR, Grigorieff, Nikolaus N and Moore, Melissa J MJ. 2002-04 Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. [PMID:11991638]
      8.Scott, Margaret Porter MP, Zappacosta, Francesca F, Kim, Eun Young EY, Annan, Roland S RS and Miller, W Todd WT. 2002-08-02 Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. [PMID:12029088]
      9.Zhou, Zhaolan Z, Licklider, Lawrence J LJ, Gygi, Steven P SP and Reed, Robin R. 2002-09-12 Comprehensive proteomic analysis of the human spliceosome. [PMID:12226669]
      10.Will, Cindy L CL and 5 more authors. 2002-09-16 Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. [PMID:12234937]