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SLC12A2

DescriptionSolute carrier family 12 member 2

Gene and Protein Information

Gene ID6558
Uniprot Accession IDs Q8N713 Q8WWH7
Ensembl ID ENSP00000262461
Symbol NKCC1 BSC BSC2 NKCC1 PPP1R141
FamilyBelongs to the SLC12A transporter family.
Sequence
MEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKSDLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp471620SLC12A2solute carrier family 12 member 29598VGNC:8637OMA, EggNOG
Macaque704672SLC12A2solute carrier family 12 member 29544Inparanoid, OMA, EggNOG
Mouse20496Slc12a2solute carrier family 12, member 210090MGI:101924Inparanoid, OMA, EggNOG
Rat83629Slc12a2solute carrier family 12 member 210116RGD:620809Inparanoid, OMA, EggNOG
Dog481490SLC12A2solute carrier family 12 member 29615VGNC:46219Inparanoid, OMA, EggNOG
Horse100073036SLC12A2solute carrier family 12 member 29796VGNC:23020Inparanoid, OMA, EggNOG
Cow286845SLC12A2solute carrier family 12 member 29913VGNC:34665Inparanoid, OMA, EggNOG
Pig100516960SLC12A2solute carrier family 12 member 29823Inparanoid, OMA, EggNOG
Opossum100022720SLC12A2solute carrier family 12 member 213616Inparanoid, OMA, EggNOG
Chicken427123SLC12A2solute carrier family 12 member 29031CGNC:10891Inparanoid, OMA
Anole lizard100555453slc12a2solute carrier family 12 member 228377Inparanoid, OMA
Zebrafish415170slc12a2solute carrier family 12 (sodium/potassium/chloride transporter), member 27955Inparanoid, OMA

Protein Classes

DTO Classes
protein    /    Transporter    /    SLC superfamily of solute carriers    /    SLC12 family of cation-coupled chloride transporters    /    Solute carrier family 12 member 2

Associated Recombinant Proteins

NameSpecification and purityExpression systemProtein labelAvailabilityView Details

Associated Antibodies

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NameSpecificationsSpecies reactivityApplicationAvailabilityView Details

Associated Approved Drugs

    Associated Active Ligands

      Associated Diseases

      NameDirect Associated TargetsDisease TypeMondoid

      Bibliography

      1.Moore-Hoon, M L ML and Turner, R J RJ. 2000-04-04 The structural unit of the secretory Na+-K+-2Cl- cotransporter (NKCC1) is a homodimer. [PMID:10736171]
      2.Selvaraj, N G NG, Prasad, R R, Goldstein, J L JL and Rao, M C MC. 2000-10-20 Evidence for the presence of cGMP-dependent protein kinase-II in human distal colon and in T84, the colonic cell line. [PMID:11042348]
      3.Vibat, C R CR, Holland, M J MJ, Kang, J J JJ, Putney, L K LK and O'Donnell, M E ME. 2001-11-15 Quantitation of Na+-K+-2Cl- cotransport splice variants in human tissues using kinetic polymerase chain reaction. [PMID:11700976]
      4.Liedtke, Carole M CM, Papay, Robert R and Cole, Thomas S TS. 2002-05 Modulation of Na-K-2Cl cotransport by intracellular Cl(-) and protein kinase C-delta in Calu-3 cells. [PMID:11943682]
      5.Schliess, Freimut F and 5 more authors. 2002-05-15 Expression and regulation of the Na(+)/K(+)/2Cl(-) cotransporter NKCC1 in rat liver and human HuH-7 hepatoma cells. [PMID:12054469]
      6.Lebeau, Catherine C and 5 more authors. 2002-09 Basolateral chloride transporters in autosomal dominant polycystic kidney disease. [PMID:12355171]
      7.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      8.Bergeron, Marc J MJ, Gagnon, Edith E, Wallendorff, Bernadette B, Lapointe, Jean-Yves JY and Isenring, Paul P. 2003-07 Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters. [PMID:12657561]
      9.Dowd, Brian F X BF and Forbush, Biff B. 2003-07-25 PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1). [PMID:12740379]
      10.Worrell, Roger T RT, Oghene, Jennifer J and Matthews, Jeffrey B JB. 2004-01 Ammonium effects on colonic Cl- secretion: anomalous mole fraction behavior. [PMID:12946942]