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SLC1A4

DescriptionNeutral amino acid transporter A

Gene and Protein Information

Gene ID6509
Uniprot Accession IDs B7Z3C0 D6W5F0
Ensembl ID ENSP00000234256
Symbol ASCT1 SATT SATT ASCT1 SPATCCM
FamilyBelongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A4 subfamily.
Sequence
MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGAALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFPSNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKLGSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFASILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQKATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
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Homologous gene and protein info.
SpeciesGene IDGene SymbolNameTax IDOther Gene IDSources
Chimp459278SLC1A4solute carrier family 1 member 49598VGNC:7717OMA, EggNOG
Macaque699288SLC1A4solute carrier family 1 member 49544OMA, EggNOG
Mouse55963Slc1a4solute carrier family 1 (glutamate/neutral amino acid transporter), member 410090MGI:2135601Inparanoid, OMA, EggNOG
Rat305540Slc1a4solute carrier family 1 member 410116RGD:735146Inparanoid, OMA, EggNOG
Dog481391SLC1A4solute carrier family 1 member 49615VGNC:46264Inparanoid, OMA, EggNOG
Horse100063163SLC1A4solute carrier family 1 member 49796VGNC:23063Inparanoid, OMA, EggNOG
Cow326577SLC1A4solute carrier family 1 member 49913VGNC:34714Inparanoid, OMA, EggNOG
Opossum100031837SLC1A4solute carrier family 1 member 413616Inparanoid, EggNOG
Chicken769612SLC1A4solute carrier family 1 member 49031CGNC:6687Inparanoid, OMA, EggNOG
Anole lizard100562665slc1a4solute carrier family 1 member 428377Inparanoid, OMA, EggNOG
Xenopus100124992slc1a4solute carrier family 1 (glutamate/neutral amino acid transporter), member 48364XB-GENE-980499Inparanoid, OMA, EggNOG
Zebrafish368885slc1a4solute carrier family 1 (glutamate/neutral amino acid transporter), member 47955ZDB-GENE-030616-566Inparanoid, OMA

Protein Classes

PANTHER Classes
protein    /    transporter    /    cation transporter    /    Neutral amino acid transporter A
DTO Classes
protein    /    Transporter    /    SLC superfamily of solute carriers    /    SLC1 family of amino acid transporters    /    Alanine/serine/cysteine transporter subfamily    /    Neutral amino acid transporter A

Associated Approved Drugs

    Associated Active Ligands

      Bibliography

      1.Marin, M M, Tailor, C S CS, Nouri, A A and Kabat, D D. 2000-09 Sodium-dependent neutral amino acid transporter type 1 is an auxiliary receptor for baboon endogenous retrovirus. [PMID:10933718]
      2.Younes, M M and 5 more authors.Expression of the neutral amino acids transporter ASCT1 in esophageal carcinomas. [PMID:11268453]
      3.Lavillette, Dimitri D and 5 more authors. 2002-07 The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors. [PMID:12050356]
      4.Strausberg, Robert L RL and 83 more authors. 2002-12-24 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. [PMID:12477932]
      5.Marin, Mariana M, Lavillette, Dimitri D, Kelly, Sean M SM and Kabat, David D. 2003-03 N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions. [PMID:12584318]
      6.Pinilla-Tenas, J J, Barber, A A and Lostao, M P MP. 2003-09-01 Transport of proline and hydroxyproline by the neutral amino-acid exchanger ASCT1. [PMID:14502423]
      7.Gerhard, Daniela S DS and 115 more authors. 2004-10 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). [PMID:15489334]
      8.Hillier, Ladeana W LW and 121 more authors. 2005-04-07 Generation and annotation of the DNA sequences of human chromosomes 2 and 4. [PMID:15815621]
      9.Kimura, Kouichi K and 31 more authors. 2006-01 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. [PMID:16344560]
      10.Weis, S S and 5 more authors. 2007-02 Changes in region- and cell type-specific expression patterns of neutral amino acid transporter 1 (ASCT-1) in the anterior cingulate cortex and hippocampus in schizophrenia, bipolar disorder and major depression. [PMID:16897601]